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科研机构
上海药物研究所 [8]
内容类型
期刊论文 [8]
发表日期
2021 [8]
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发表日期:2021
专题:上海药物研究所
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STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Wu, Bing
;
Xu, Meng-meng
;
Fan, Chen
;
Feng, Chun-lan
;
Lu, Qiu-kai
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2022/01/18
acute lung injury
STING
vascular endothelial cells
inflammatory cytokines
chemokines
chemotaxis
Chiral Phosphoric Acid Catalyzed Asymmetric Desymmetrization of para-Quinamines with Isocyanates: Access to Functionalized Imidazolidin-2-one Derivatives
期刊论文
ORGANIC LETTERS, 2021, 卷号: 23, 期号: 20, 页码: 7873-7877
作者:
Hu, Kai-Wen
;
You, Xiao
;
Wang, Jin-Zheng
;
Wen, Xiaoan
;
Sun, Hongbin
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/12/16
Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Diversity-oriented synthesis of cembranoid derivatives as potential anti-inflammatory agents
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 111, 页码: 8
作者:
Zhang, Cong
;
Li, Heng
;
Liu, Jin
;
Liu, Moting
;
Zhang, Hao
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/08/17
Marine natural product
Cembranoid
Anti-inflammation
molecular docking
structuremodification
Structure Activity Relationship
A novel mouse model for liver metastasis of prostate cancer reveals dynamic tumour-immune cell communication
期刊论文
CELL PROLIFERATION, 2021, 页码: 12
作者:
Liu, Kaiyuan
;
Jing, Na
;
Wang, Deng
;
Xu, Penghui
;
Wang, Jinming
收藏
  |  
浏览/下载:96/0
  |  
提交时间:2021/08/17
liver metastasis
metastasis‐
associated immune cell
metastatic microenvironment
prostate cancer
Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Jiang, Kai-long
;
Tong, Le-xian
;
Wang, Tao
;
Wang, Han-lin
;
Hu, Xiao-bei
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2021/05/24
CHK1 inhibitors
PY34
drug sensitivity
c-Myc
hematologic malignancies
Discovery of New alpha-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation
期刊论文
FRONTIERS IN CHEMISTRY, 2021, 卷号: 9, 页码: 9
作者:
Liu, Shan-Kui
;
Hao, Haifang
;
Bian, Yuan
;
Ge, Yong-Xi
;
Lu, Shengyuan
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/05/24
α
-glycosidase
virtual screening
cytotoxicity
type 2 diabetes
molecular docking
Novel bivalent BET inhibitor N2817 exhibits potent anticancer activity and inhibits TAF1
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 185, 页码: 14
作者:
Wu, Qian
;
Chen, Dan-Qi
;
Sun, Lin
;
Huan, Xia-Juan
;
Bao, Xu-Bin
收藏
  |  
浏览/下载:116/0
  |  
提交时间:2021/05/24
N2817
Bivalent BET inhibitors
Monovalent BET inhibitors
TAF1
Anticancer activity
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