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科研机构
上海药物研究所 [18]
内容类型
期刊论文 [18]
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2020 [1]
2019 [2]
2018 [2]
2017 [1]
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2015 [1]
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Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 11, 页码: 5
作者:
Satheeshkumar, Rajendran
;
Zhu, Rui
;
Feng, Bo
;
Huang, Chao
;
Gao, Ya
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
Heterocyclic bis-aryl amides
PTP1B
SHP2
Inhibitors
Structure-activity relationships (SAR)
Gold-catalyzed Rapid Construction of Nitrogen-containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity
期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2019, 卷号: 361, 期号: 6, 页码: 1419-1440
作者:
Qiao, Jin
;
Jia, Xiuwen
;
Li, Pinyi
;
Liu, Xiaoyan
;
Zhao, Jingwei
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
Alkynes
Amines
Cascade reaction
Compound library
Gold
Scaffold diversity
Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 602-614
作者:
Dong, Xiao-Wu
;
Zhang, Jian-Kang
;
Xu, Lei
;
Che, Jin-Xin
;
Cheng, Gang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
Proteasome inhibitors
Tripeptide
Covalent docking
Interaction mode
Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 428-441
作者:
Zhang, Qiumeng
;
Shen, Qianqian
;
Gao, Lixin
;
Tong, Linjiang
;
Li, Jia
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
Aurora A
Aurora B
KDR
Multi-targeted
Anticancer
Heterocyclic
Albatredines A and B, a pair of epimers with unusual natural heterocyclic skeletons from edible mushroom Albatrellus confluens
期刊论文
RSC ADVANCES, 2018, 卷号: 8, 期号: 42, 页码: 23914-23918
作者:
Zhang, Shuaibing
;
Huang, Ying
;
He, Shijun
;
Chen, Heping
;
Li, Zhenghui
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
Design, synthesis and biological evaluation of indolin-2-one-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase3 (FLT3)
期刊论文
European journal of medicinal chemistry, 2017, 卷号: 127, 页码: 72-86
作者:
Ma, Fei
;
Liu, Peng
;
Lei, Min
;
Liu, Jian
;
Wang, Hongtao
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 122, 页码: 756-769
作者:
Meng, Ge
;
Zheng, Meilin
;
Wang, Mei
;
Tong, Jing
;
Ge, Weijuan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
1,3-Thiazolidine-4-one
PTP1B
Pyrrole
Pyridine
Dock
SAR
Flueggether A and Virosinine A, Anti-HIV Alkaloids from Flueggea virosa
期刊论文
ORGANIC LETTERS, 2015, 卷号: 17, 期号: 24, 页码: 6274-6277
作者:
Zhang, Hua
;
Zhu, Kong-Kai
;
Han, Ying-Shan
;
Luo, Cheng
;
Wainberg, Mark A.
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Rapid Generation of Privileged Substructure-Based Compound Libraries with Structural Diversity and Drug-Likeness
期刊论文
ACS COMBINATORIAL SCIENCE, 2014, 卷号: 16, 期号: 4, 页码: 184-191
作者:
Zhang, Lei
;
Zheng, Mingyue
;
Zhao, Fei
;
Zhai, Yun
;
Liu, Hong
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
indole
diversity-oriented synthesis
drug-like
privileged structure
microwave
Discovery of pyrazole as C-terminus of selective BACE1 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 68, 页码: 270-283
作者:
Zou, Yiquan
;
Xu, Lei
;
Chen, Wuyan
;
Zhu, Yiping
;
Chen, Tiantian
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Alzheimer's disease
BACE1
C-terminus
Click chemistry
In situ screening assay
Pyrazole
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