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科研机构
上海药物研究所 [1470]
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期刊论文 [1384]
项目 [58]
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2021 [86]
2020 [104]
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Pharmacol... [39]
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Multi-level fingerprinting and cardiomyocyte protection evaluation for comparing polysaccharides from six Panax herbal medicines
期刊论文
CARBOHYDRATE POLYMERS, 2022, 卷号: 277, 页码: 10
作者:
Liu, Jie
;
Wang, Hong-da
;
Yang, Fei-fei
;
Chen, Bo-xue
;
Li, Xue
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2022/01/04
Panax
Polysaccharide
Oligosaccharide spectrum
Untargeted metabolomics
Cardiomyocyte protection
Application of metabolomics for revealing the interventional effects of functional foods on metabolic diseases
期刊论文
FOOD CHEMISTRY, 2022, 卷号: 367, 页码: 14
作者:
Fu, Jia
;
Zhang, Le-Le
;
Li, Wei
;
Zhang, Yan
;
Zhang, Yamei
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/11/04
Functional foods
Metabolomics
Metabolites
Metabolic diseases
Food processing
The regulatory role of MiR-203 in oxidative stress induced cell injury through the CBS/H2S pathway
期刊论文
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2022, 卷号: 118, 页码: 31-38
作者:
Zhang, Qiuyan
;
Shen, Zhuqing
;
Shen, Yaqi
;
Ma, Muye
;
Jue, Hao
收藏
  |  
浏览/下载:223/0
  |  
提交时间:2022/01/04
Cerebral infarction
Cystathionine-beta-synthase
miRNA-203
Hydrogen sulfide
A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters
期刊论文
CHEMICAL SCIENCE, 2021, 卷号: 13, 期号: 1, 页码: 247-256
作者:
Dong, Lei
;
Zhang, Min-Yu
;
Han, Hai-Hao
;
Zang, Yi
;
Chen, Guo-Rong
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/01/18
Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Yang, Xiangbo
;
Lu, Huimin
;
Xie, Hang
;
Zhang, Binbin
;
Nie, Tianqing
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/01/18
Binding studies
Drug discovery
Necroptosis
RIPK1 inhibitors
Sepsis
A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 226, 页码: 11
作者:
Cheng, Zhiyang
;
Huang, Ying
;
Shen, Qianqian
;
Zhao, Yangrong
;
Wang, Lei
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2021/11/04
Cancer
beta-glucuronidase
Bioconjugation
Albumin
Camptothecin
Conformational polymorphs of isotretinoin and their impact on physicochemical and biological properties
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 卷号: 610, 页码: 10
作者:
Cheng, Yinxiang
;
Rong, Xiaoyi
;
Xia, Mengyuan
;
Zhang, Zaiyong
;
Wang, Jian-Rong
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  |  
浏览/下载:73/0
  |  
提交时间:2022/01/04
Polymorph
Isotretinoin
Stability
Solubility
Bioavailability
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:
Zhang, Chun
;
Sun, Yi-Tao
;
Gao, Li-Xin
;
Feng, Bo
;
Yan, Xue
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/01/18
Photoactivatable nanogenerators of reactive species for cancer therapy
期刊论文
BIOACTIVE MATERIALS, 2021, 卷号: 6, 期号: 12, 页码: 4301-4318
作者:
Zheng, Xiaohua
;
Jin, Yilan
;
Liu, Xiao
;
Liu, Tianqing
;
Wang, Weiqi
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/12/16
Reactive oxygen species
Reactive nitrogen species
Alkyl radicals
Carbon monoxide
Phototherapy
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