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上海药物研究所 [22]
湖南大学 [22]
大连化学物理研究所 [11]
山东大学 [8]
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期刊论文 [112]
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2019 [112]
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发表日期:2019
内容类型:期刊论文
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Palladium-Catalyzed Highly Enantioselective Arylation of Cyclic N-Sulfonyl alpha-Ketimino Esters towards the Synthesis of alpha-Quaternary Chiral Amino Acid Derivatives
期刊论文
CHEMCATCHEM, 2019, 页码: 6
作者:
Wu, Chun-Yan
;
Xu, Ming-Hua
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
alpha-quaternary chiral amino acid
palladium
asymmetric catalysis
arylation
alpha-ketimino esters
Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 23
作者:
Zou, Yi
;
Hu, Yue
;
Ge, Shushan
;
Zheng, Yingbo
;
Li, Yuezhen
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
IDO1
Heme
T cell
Cancer immunotherapy
Virtual screening
Drug design
Molecular dynamics simulation
Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays
期刊论文
GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 卷号: 16, 期号: 6, 页码: 416-427
作者:
Hou, Tingjun
;
Li, Dan
;
Chang, Shan
;
Xu, Lei
;
Sun, Huiyong
收藏
  |  
浏览/下载:261/0
  |  
提交时间:2019/06/24
Androgen receptor
AR ligand
Virtual screening
AR agonist
AR antagonist
A minimalist peptide ligand for IgG by minimizing the binding domain of protein A
期刊论文
BIOCHEMICAL ENGINEERING JOURNAL, 2019, 卷号: 151, 页码: 8
作者:
Wang, Weiying
;
Hao, Dongxia
;
Ge, Jia
;
Zhao, Lan
;
Huang, Yongdong
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/05/06
Affinity Purification Chromatography
Minimalist Peptide
Protein a
Igg
Rational Design
Targeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling
期刊论文
CELL CHEMICAL BIOLOGY, 2019, 卷号: 26, 期号: 10, 页码: 1417-+
作者:
Jiang, Chenxiao
;
Tang, Yegen
;
Ding, Lulu
;
Tan, Renke
;
Li, Xiaojing
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  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
DeepCPI: A Deep Learning-based Framework for Large-scale in silico Drug Screening
期刊论文
GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 卷号: 17, 期号: 5, 页码: 478-495
作者:
Wan, Fangping
;
Zhu, Yue
;
Hu, Hailin
;
Dai, Antao
;
Cai, Xiaoqing
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  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Deep learning
Machine learning
Drug discovery
In silico drug screening
Compound-protein interaction prediction
Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 5, 页码: 997-1007
作者:
Trevarton, Alexander J.
;
Zhou, Yan
;
Yang, Dehua
;
Rewcastle, Gordon W.
;
Flanagan, Jack U.
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  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
Cancer
YB-1
Luciferase
AlphaScreen
Transcription factor
Single-stranded DNA
Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 16, 页码: 7473-7488
作者:
Wang, Yulan
;
Dai, Yang
;
Wu, Xiaowei
;
Li, Fei
;
Liu, Bo
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  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Improving the Virtual Screening Ability of Target-Specific Scoring Functions Using Deep Learning Methods
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 11
作者:
Wang, Dingyan
;
Cui, Chen
;
Ding, Xiaoyu
;
Xiong, Zhaoping
;
Zheng, Mingyue
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2020/07/01
virtual screening
target-specific scoring function
deep learning
drug discovery
DUD-E
A chemoenzymatic approach enables the site-specific conjugation of recombinant proteins
期刊论文
ELECTROPHORESIS, 2019, 卷号: 40, 期号: 16-17, 页码: 2125-2128
作者:
Wang, Yan
;
Dong, Mingming
;
Ye, Mingliang
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  |  
浏览/下载:69/0
  |  
提交时间:2019/12/02
Biorthogonal chemistry
Chemoenzymatic approach
Site-specific conjugation
Tyrosine phosphorylation
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