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浏览/检索结果: 共22条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li;  Tao, Hong-Rui;  Cheng, Zhi-Qiang;  Jiang, Cheng-Shi 收藏  |  浏览/下载：100/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation   Metabolic profiling analysis of corilagin in vivo and in vitro using high-performance liquid chromatography quadrupole time-of-flight mass spectrometry 期刊论文 Journal of pharmaceutical and biomedical analysis, 2018, 卷号: 165, 页码: 251-260 作者:  Yisimayili, Zainaipuguli;  Guo, Xiaozhen;  Liu, Huan;  Xu, Zhou;  Abdulla, Rahima 收藏  |  浏览/下载：70/0  |  提交时间：2019/01/08 Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298 作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan 收藏  |  浏览/下载：129/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Arginine methylation  Virtual screening  Molecular docking  Molecular dynamics simulation   Structural characterization and anti-A549 lung cancer cells bioactivity of a polysaccharide from Houttuynia cordata 期刊论文 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 卷号: 120, 页码: 288-296 作者:  Han, Kun;  Jin, Can;  Chen, Huanjun;  Wang, Peipei;  Yu, Mei 收藏  |  浏览/下载：78/0  |  提交时间：2019/01/08 Houttuynia cordata  Pectin  Anti-cancer   Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 649-654 作者:  Zhang, Li;  Chen, Yantao;  Liu, Na;  Li, Linjuan;  Xiao, Senhao 收藏  |  浏览/下载：38/0  |  提交时间：2019/01/08 Pyrimidylaminoquinoline  Nonnucleoside DOT1L inhibitors  Amino side chains  Mixed-linage leukemia  Histone lysine methyltransferase   Metabolic profiles and pharmacokinetics of picroside I in rats by liquid chromatography combined with electrospray ionization tandem mass spectrometry 期刊论文 Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018, 卷号: 1095, 页码: 157-165 作者:  Xiong, Kai;  Ju, Zhengcai;  Zhang, Tong;  Wang, Zhengtao;  Han, Han 收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08 Deciphering the role of dimer interface in intrinsic dynamics and allosteric pathways underlying the functional transformation of DNMT3A 期刊论文 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2018, 卷号: 1862, 期号: 7, 页码: 1667-1679 作者:  Liang, Zhongjie;  Hu, Junchi;  Yan, Wenying;  Jiang, Hualiang;  Hu, Guang 收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 Conformational dynamics  Allosteric communication  Elastic network models, network theory, coevolution analysis   Structural characterization of a galactan from Ophiopogon japonicus and anti-pancreatic cancer activity of its acetylated derivative 期刊论文 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 卷号: 113, 页码: 907-915 作者:  Gu, Dan;  Huang, Lulin;  Chen, Xia;  Wu, Qianhu;  Ding, Kan 收藏  |  浏览/下载：74/0  |  提交时间：2019/01/08 Ophiopogon japonicus  Polysaccharide  Acetylated derivative  Apoptosis  Anti-pancreatic cancer   Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 9, 页码: 1476-1483 作者:  Zhu, Kongkai;  Jiang, Chengshi;  Tao, Hongrui;  Liu, Jingqiu;  Zhang, Hua 收藏  |  浏览/下载：59/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Resynthesis  Virtual screening  Molecular docking  Molecular dynamics simulation   Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays 期刊论文 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2018, 卷号: 58, 期号: 5, 页码: 1066-1073 作者:  Ye, Fei;  Zhang, Weiyao;  Ye, Xiaoqing;  Jin, Jia;  Lv, Zhengbing 收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08