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科研机构
上海药物研究所 [12]
内容类型
期刊论文 [12]
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2021 [2]
2020 [2]
2019 [1]
2018 [1]
2017 [2]
2015 [2]
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Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK
期刊论文
CLINICAL SCIENCE, 2021, 卷号: 135, 期号: 19, 页码: 2243-2263
作者:
Elksnis, Andris
;
Schiffer, Tomas A.
;
Palm, Fredrik
;
Wang, Yun
;
Cen, Jing
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/12/01
A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage
期刊论文
METABOLISM-CLINICAL AND EXPERIMENTAL, 2021, 卷号: 120, 页码: 12
作者:
Huang, Suling
;
Wu, Yanwei
;
Zhao, Zhuohui
;
Wu, Bing
;
Sun, Kai
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2021/08/17
Macrophage
NLRP3 inflammasome
Hepatic lipid accumulation
NASH
FXR
Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway
期刊论文
MOLECULAR METABOLISM, 2020, 卷号: 41, 页码: 15
作者:
Liu, Siwen
;
Huang, Suling
;
Wu, Xingde
;
Feng, Ying
;
Shen, Yu
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2020/12/24
Salt-inducible kinase 1
Phanginin A
Phosphodiesterase 4
Gluconeogenesis
cAMP
Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer
期刊论文
SCIENCE ADVANCES, 2020, 卷号: 6, 期号: 8, 页码: 13
作者:
Qin, Yuanyuan
;
Chen, Weilong
;
Jiang, Guojuan
;
Zhou, Lei
;
Yang, Xiaoli
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2020/07/01
TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice
期刊论文
METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 卷号: 99, 页码: 45-56
作者:
Huang, Suling
;
Ma, Shanyao
;
Ning, Mengmeng
;
Yang, Wenji
;
Ye, Yangliang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
TGR5
Glucose homeostasis
Insulin resistance
Skeletal muscle
Type 2 diabetes
Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Xie, Wei
;
Ye, Yangliang
;
Feng, Ying
;
Xu, Tifei
;
Huang, Suling
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
cAMP
gluconeogenesis
linderane
phosphodiesterase
type 2 diabetes
Design and synthesis of Atglistatin derivatives as adipose triglyceride lipase inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1122-1133
作者:
Jin, Jiyu
;
Huang, Suling
;
Wang, Lei
;
Leng, Ying
;
Lu, Wei
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
adipose triglyceride lipase inhibitors
Atglistatin
structure-activity relationship
thiourea
Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2017, 卷号: 13, 期号: 1, 页码: 1-12
作者:
Huang, Shujuan
;
Huang, Suling
;
Wang, Xi
;
Zhang, Qingli
;
Liu, Jia
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
lipin-1
skeletal muscle
insulin resistance
lipid metabolism
ceramide
Design and Synthesis of Novel Arctigenin Analogues for the Amelioration of Metabolic Disorders
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2015, 卷号: 6, 期号: 4, 页码: 386-391
作者:
Duan, Shudong
;
Huang, Suling
;
Gong, Jian
;
Shen, Yu
;
Zeng, Limin
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Natural product
arctigenin analogues
2-deoxyglucose uptake in L6 myotubes
amelioration of metabolic disorders
yhhu981anovelcompoundstimulatesfattyacidoxidationviatheactivationofampkandameliorateslipidmetabolismdisorderinobobmice
期刊论文
actapharmacologicasinica, 2015, 卷号: 36, 期号: 3, 页码: 343
作者:
Zeng Hongliang
;
Huang Suling
;
Xie Fuchun
;
Zeng Limin
;
Hu Youhong
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
PROTEIN-KINASE ACTIVATION
RAT SOLEUS MUSCLE
SKELETAL-MUSCLE
INSULIN SENSITIVITY
MALONYL-COA
MITOCHONDRIAL BIOGENESIS
MYOBLAST DIFFERENTIATION
ENERGY-EXPENDITURE
DEFICIENT MICE
GLUCOSE-UPTAKE
yhhu981
fatty acid oxidation
fatty acid synthesis
AMPK
compound C
sirtinol
EX527
STO609
AICAR
metformin
metabolism disorder
C2C12 myotubes
HepG2 cells
ob/ob mice
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