Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer

doi:10.1126/sciadv.aaw9960

	Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer
	Qin, Yuanyuan 3,4,5; Chen, Weilong 3,4,5; Jiang, Guojuan 3,4; Zhou, Lei 3,4,5; Yang, Xiaoli 3,4; Li, Hongqi 1,2; He, Xueyan 3,4; Wang, Han-lin 6,7; Zhou, Yu-bo 7; Huang, Shenglin 3,4
刊名	SCIENCE ADVANCES
	2020-02-01
卷号	6 期号:8 页码:13
ISSN号	2375-2548
DOI	10.1126/sciadv.aaw9960
通讯作者	Liu, Suling(suling@fudan.edu.cn)
英文摘要	Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, little is known about the regulatory mechanisms of MSN in TNBC. We found that MSN significantly stimulated breast cancer cell proliferation and invasion in vitro and tumor growth in vivo, requiring the phosphorylation of MSN and a nucleoprotein NONO-assisted nuclear localization of phosphorylated MSN with protein kinase C (PKC) and then the phosphoryl-ation activation of CREB signaling by PKC. Our study also demonstrated that targeting MSN, NONO, or CREB significantly inhibited breast tumor growth in vivo. These results introduce a new understanding of MSN function in breast cancer and provide favorable evidence that MSN or its downstream molecules might serve as new targets for TNBC treatment.
资助项目	National Key Research and Development Program of China (Stem Cell and Translational Research)[2016YFA0101202] ; MOST grant[2015CB553800] ; NSFC[81772799] ; NSFC[81530075] ; NSFC[81930075] ; Program for Outstanding Medical Academic Leader[2019LJ04] ; Fudan-SIMM Joint Research Fund[FU-SIMM20172007] ; Fudan University Research Foundation[IDH 1340042] ; Research Foundation of the Fudan University Shanghai Cancer Center[YJRC1603]
WOS关键词	ERM PROTEINS ; MOESIN ; METASTASIS ; DISEASE ; PHOSPHORYLATION ; PROLIFERATION ; PROGRESSION ; STATISTICS ; EXPRESSION ; INVASION
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号	WOS:000514842000004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281243]
专题	中国科学院上海药物研究所
通讯作者	Liu, Suling
作者单位	1.Fudan Univ, Zhongshan Hosp, Endoscopy Ctr, Shanghai, Peoples R China 2.Fudan Univ, Zhongshan Hosp, Endoscopy Res Inst, Shanghai, Peoples R China 3.Fudan Univ, Shanghai Canc Ctr, Shanghai Med Coll,Canc Inst, Key Lab Breast Canc Shanghai,Innovat Ctr Cell Sig, Shanghai 200032, Peoples R China 4.Fudan Univ, Inst Biomed Sci, Shanghai Med Coll,Canc Inst, Key Lab Breast Canc Shanghai,Innovat Ctr Cell Sig, Shanghai 200032, Peoples R China 5.Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Innate Immun & Chron Dis, Hefei 230027, Anhui, Peoples R China 6.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Qin, Yuanyuan,Chen, Weilong,Jiang, Guojuan,et al. Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer[J]. SCIENCE ADVANCES,2020,6(8):13.
APA	Qin, Yuanyuan.,Chen, Weilong.,Jiang, Guojuan.,Zhou, Lei.,Yang, Xiaoli.,...&Liu, Suling.(2020).Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer.SCIENCE ADVANCES,6(8),13.
MLA	Qin, Yuanyuan,et al."Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer".SCIENCE ADVANCES 6.8(2020):13.