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CORC

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PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation 期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 7, 页码: 10
作者:  Yang, Jun;  Wang, Juan;  Liu, Yuan;  Zhang, Yu;  Huang, Wenjing
收藏  |  浏览/下载：42/0  |  提交时间：2021/08/17
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma 期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 2, 页码: 488-504
作者:  Liu, Xiaohua;  Zhang, Yu;  Li, Yalei;  Wang, Juan;  Ding, Huaqian
收藏  |  浏览/下载：29/0  |  提交时间：2021/05/24
Medulloblastoma: Molecular understanding, treatment evolution, and new developments 期刊论文
PHARMACOLOGY & THERAPEUTICS, 2020, 卷号: 210, 页码: 13
作者:  Liu, Xiaohua;  Ding, Chunyong;  Tan, Wenfu;  Zhang, Ao
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01
Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 21, 页码: 9983-9989
作者:  Zhou, Fang;  Ding, Kang;  Zhou, Yiqing;  Liu, Yang;  Liu, Xiaoyan
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01
Development of high potent and selective Bcl-2 inhibitors bearing the structural elements of natural product artemisinin 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 159, 页码: 149-165
作者:  Liu, Xiaohua;  Zhang, Yu;  Huang, Wenjing;  Luo, Jia;  Li, Yang
收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08
Design, synthesis and pharmacological evaluation of new acyl sulfonamides as potent and selective Bcl-2 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 2, 页码: 443-454
作者:  Liu, Xiaohua;  Zhang, Yu;  Huang, Wenjing;  Tan, Wenfu;  Zhang, Ao
收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08
Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 19, 页码: 8218-8245
作者:  Liu, Gang;  Huang, Wenjing;  Wang, Juan;  Liu, Xiaohua;  Yang, Jun
收藏  |  浏览/下载：11/0  |  提交时间：2019/01/08
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand 期刊论文
NATURE COMMUNICATIONS, 2017, 卷号: 8
作者:  Zhang, Xianjun;  Zhao, Fei;  Wu, Yiran;  Yang, Jun;  Han, Gye Won
收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08
Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 24, 页码: 11050-11068
作者:  Liu, Gang;  Xue, Ding;  Yang, Jun;  Wan, Juan;  Liu, Xiaohua
收藏  |  浏览/下载：53/0  |  提交时间：2019/01/08

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