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The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis 期刊论文
Clinica Chimica Acta, 2016, 卷号: 456, 页码: 81-88
作者:  Huang, Shifang;  Chen, Linxi;  Lu, Liqun;  Li, Lanfang*
收藏  |  浏览/下载:7/0  |  提交时间:2019/12/27
AT-1  angiotensin II type 1 receptor  VSMC  vascular smooth muscle cell  TGF-β1  transforming growth factor-β1  Ang-II  angiotensin II  ECM  extracellular matrix  CKD  chronic kidney disease  eNOS  endothelial nitric oxide synthase  UUO  unilateral ureteral obstruction  EMT  epithelial–mesenchymal transition  CAD  coronary artery disease  PAI-1  plasminogen activator inhibitor-1  SphK1  sphingosine kinase1  Post-MI  post-myocardial infarction  BMCs  bone marrow cells  HSCs  hepatic stellate cells  BA  biliary atresia  AII  angiotensin II  ET-1  endothelin-1  PDGFRβ  platelet-derived growth factor receptor β  ALC  alcoholic liver cirrhosis  HCV  hepatitis C virus  BA  biliary atresia  BPD  bronchopulmonary dysplasia  ARDS  acute respiratory distress syndrome  OA  oleic acid  PH  pulmonary hypertension  KLF2  Kruppel-like factor 2  Apelin–APJ  Renal fibrosis  Cardiac fibrosis  Liver fibrosis  Pulmonary fibrosis  
PI3K/Akt signaling in osteosarcoma 期刊论文
Clinica Chimica Acta, 2015, 卷号: 444, 期号: Volume 444, 页码: 182-192
作者:  Zhang, Jian;  Yu, Xiao-Hua;  Yan, Yi-Guo;  Wang, Cheng;  Wang, Wen-Jun*
收藏  |  浏览/下载:13/0  |  提交时间:2019/12/27
OS  osteosarcoma  PI3K  phosphatidylinositol 3-kinase  PTEN  phosphatase and tensin homolog  mTOR  mammalian target of rapamycin  RTKs  receptor tyrosine kinases  PDGFR  platelet-derived growth factor receptor  IGF1R  insulin-like growth factor 1 receptor  PIP2  phosphatidylinositol 4,5-biphosphate  PIP3  phosphatidylinositol 3,4,5-triphosphate  PDK1  phosphoinositide-dependent kinase 1  PH  pleckstrin homology  CDK  cyclin-dependent kinase  NF-κB  nuclear factor-κB  MDM2  Murine double minute 2  Rb  retinoblastoma  CSCs  cancer stem cells  CXCR7  CXC chemokine receptor 7  GA  gallic acid  miRNAs  microRNAs  TNF  tumor necrosis factor  HIF-1  hypoxia-inducible factor-1  ET-1  endothelin-1  ETAR  endothelin A receptor  MMP  matrix metalloproteinase.  OS  PI3K  Akt  PTEN  mTOR  
Interleukin-1β in intervertebral disk degeneration 期刊论文
Clinica Chimica Acta, 2015, 卷号: 450, 页码: 262-272
作者:  Yang, Wei;  Yu, Xiao-Hua;  Wang, Cheng;  He, Wen-Si;  Zhang, Shu-Jun
收藏  |  浏览/下载:12/0  |  提交时间:2019/12/27
IDD  intervertebral disk degeneration  IL-1  interleukin-1  IVD  intervertebral disk  ECM  extracellular matrix  LBP  low back pain  MMPs  matrix metalloproteinases  NP  nucleus pulposus  AF  annulus fibrosus  Col II  type II collagen  Col I  type I collagen  NTP  N-terminal peptide  NLS  nuclear localization sequence  IL-1RII  IL-1 receptor type II  TLRs  Toll-like receptors  IL-1RI  IL-1 receptor type I  IL-1RAcP  IL-1 receptor accessory protein  TIR  Toll-like/IL-1 receptor  MyD88  myeloid differentiation factor 88  TNF  tumor necrosis factor  NF-κB  nuclear factor-kappa B  MAPK  mitogen-activated protein kinase  IL-1Ra  IL-1 receptor antagonist  IFN-γ  interferon-γ  CCL  CC chemokine ligand  CXCL  CX chemokine ligand  ADAMTSs  a disintegrin and metalloprotease with thrombospondin motifs  TIMPs  tissues inhibitors of metalloproteinases  VEGF  vascular endothelial growth factor  NGF  nerve growth factor  BDNF  brain-derived neurotrophic factor  ROS  reactive oxygen species  SOD  superoxide dismutase  CAT  catalase  miRNAs  microRNAs  MSCs  mesenchymal stem cells  PRP  platelet-rich plasma  IL-1  IDD  Inflammatory responses  Angiogenesis  Apoptosis  
Interleukin-1β in intervertebral disk degeneration 期刊论文
Clinica Chimica Acta, 2015, 卷号: 450, 页码: 262-272
作者:  WeiYang;  Xiao-HuaYu;  ChengWang;  Wen-SiHe;  Shu-JunZhang
收藏  |  浏览/下载:9/0  |  提交时间:2019/12/27
IDD  intervertebral disk degeneration  IL-1  interleukin-1  IVD  intervertebral disk  ECM  extracellular matrix  LBP  low back pain  MMPs  matrix metalloproteinases  NP  nucleus pulposus  AF  annulus fibrosus  Col II  type II collagen  Col I  type I collagen  NTP  N-terminal peptide  NLS  nuclear localization sequence  IL-1RII  IL-1 receptor type II  TLRs  Toll-like receptors  IL-1RI  IL-1 receptor type I  IL-1RAcP  IL-1 receptor accessory protein  TIR  Toll-like/IL-1 receptor  MyD88  myeloid differentiation factor 88  TNF  tumor necrosis factor  NF-κB  nuclear factor-kappa B  MAPK  mitogen-activated protein kinase  IL-1Ra  IL-1 receptor antagonist  IFN-γ  interferon-γ  CCL  CC chemokine ligand  CXCL  CX chemokine ligand  ADAMTSs  a disintegrin and metalloprotease with thrombospondin motifs  TIMPs  tissues inhibitors of metalloproteinases  VEGF  vascular endothelial growth factor  NGF  nerve growth factor  BDNF  brain-derived neurotrophic factor  ROS  reactive oxygen species  SOD  superoxide dismutase  CAT  catalase  miRNAs  microRNAs  MSCs  mesenchymal stem cells  PRP  platelet-rich plasma  IL-1  IDD  Inflammatory responses  Angiogenesis  Apoptosis  
MicroRNAs: New players in intervertebral disc degeneration 期刊论文
Clinica Chimica Acta, 2015, 卷号: 450, 页码: 333-341
作者:  Wang, Cheng;  Wang, Wen-Jun;  Yan, Yi-Guo;  Xiang, Yong-Xiao;  Zhang, Jian
收藏  |  浏览/下载:22/0  |  提交时间:2019/12/27
IVD  intervertebral disc  NP  nucleus pulposus  AF  annulus fibrosus  CEPs  cartilaginous endplates  IDD  intervertebral disc degeneration  ECM  extracellular matrix  miRNAs  microRNAs  RNA pol  RNA polymerase  DGCR8  DiGeorge syndrome critical gene 8  Exp 5  exportin 5  TRBP  transactivating response RNA-binding protein  RISC  RNA-induced silencing complex  Ago  Argonaute  PI3K  phosphoinositide 3-kinase  MAPK  mitogen-activated protein kinase  TGF-β  transforming growth factor-β  PDGF  platelet-derived growth factor  IGF  insulin-like growth factor  EGF  epidermal growth factor  CDKI1B  cyclin-dependent kinase inhibitor 1B  TNF-α  tumor necrosis factor-α  FADD  Fas-associated death domain-containing protein  Col II  type II collagen  Col I  type I collagen  MMPs  matrix metalloproteinases  ADAMTSs  a disintegrin and metalloprotease with thrombospondin motifs  Col I  type I collagen  Col II  type II collagen  FGF2  fibroblast growth factor 2  FGFR  fibroblast growth factor receptor  IL-1β  interleukin-1β  NGF  nerve growth factor  HOXD10  homeobox D10  MiRNAs  IDD  NP cells  Apoptosis  Cell proliferation  
Apelin and its receptor APJ in cardiovascular diseases 期刊论文
Clinica chimica acta, international journal of clinical chemistry, 2014, 卷号: 428, 页码: 1-8
作者:  Yu, Xiao-Hua*;  Tang, Zhi-Bin;  Liu, Li-Jing;  Qian, Hong;  Tang, Shi-Lin
收藏  |  浏览/下载:8/0  |  提交时间:2019/12/27
ABCA1  ACAT1  APJ  ATP-binding cassette transporter A1  Ang II  Ang-1  Apelin  Atherosclerosis  BMP  BNP  CAD  COX-2  FGF2  GSK  HDAC  HIF-1alpha  Heart failure  Hypertension  ICAM-1  IRS1  JNK  MCP-1  MEF2  MIRI  NO  PAH  PDGF-BB  PGE2  PI3K  PKB  PKC  PPAR response elements  PPREs  TGF-beta  TNF-alpha  VCAM-1  VEGFA  VSMC  acyl coenzyme A:cholesterol acyltransferase-1  angiopoietin-1  angiotensin II  apo E  apolipoprotein E  bone morphogenic protein  brain natriuretic peptide  c-Jun N-terminal kinase  coronary heart disease  cyclooxygenase-2  fibroblast growth factor 2  glycogen synthase kinase  histone deacetylase  hypoxia-inducible factor 1alpha  insulin receptor substrate 1  intercellular adhesion molecule-1  monocyte chemoattractant protein-1  myocardial ischemia-reperfusion injury  myocyte enhancer factor 2  nitric oxide  phosphatidylinositol 3-kinase  platelet-derived growth factor-BB  prostaglandin E2  protein kinase B  protein kinase C  pulmonary arterial hypertension  transforming growth factor-beta  tumor necrosis factor-alpha  vascular cell adhesion molecule-1  vascular endothelial growth factor type A  vascular smooth muscle cell  


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