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科研机构
上海药物研究所 [34]
内容类型
期刊论文 [34]
发表日期
2021 [5]
2019 [1]
2018 [6]
2017 [4]
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2015 [3]
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The double faced role of xanthine oxidoreductase in cancer
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Chen, Man-Man
;
Meng, Ling-Hua
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/01/04
xanthine oxidoreductase (XOR)
ROS
uric acid
cancer therapy
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Zou, Hui-xi
;
Zhang, Yu-feng
;
Zhong, Da-fang
;
Jiang, Yong
;
Liu, Fei
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/01/04
furmonertinib
autoinduction
food effect
alkaline phosphatase
body weight
pharmacokinetics
modeling and simulation
NSCLC
Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9458-9483
作者:
Huang, Huoming
;
Li, Xueping
;
Xie, Peng
;
Li, Xinwei
;
Xu, XueJun
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/08/17
Molecular Dynamics Simulations Reveal the Modulated Mechanism of STING Conformation
期刊论文
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021, 页码: 15
作者:
Chen, Li
;
Zhao, Shuang
;
Zhu, Yanyan
;
Liu, Yongsheng
;
Li, Huiyu
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/08/17
STING
Small molecule
Binding site
Modulated mechanism
Molecular dynamics simulation
pi-pi stacking interaction
Full-Length Transcriptome Analysis of Plasmodium falciparum by Single-Molecule Long-Read Sequencing
期刊论文
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2021, 卷号: 11, 页码: 11
作者:
Yang, Mengquan
;
Shang, Xiaomin
;
Zhou, Yiqing
;
Wang, Changhong
;
Wei, Guiying
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2021/05/24
Plasmodium falciparum
small protein
long non-coding RNA
alternative splicing
full-length RNA-seq
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288
作者:
Dong, Xiaowu
;
Zhan, Wenhu
;
Zhao, Mengting
;
Che, Jinxin
;
Dai, Xiaoyang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Baicalin relaxes vascular smooth muscle and lowers blood pressure in spontaneously hypertensive rats
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 111, 页码: 325-330
作者:
Ding, Liliqiang
;
Jia, Chenglin
;
Zhang, Yong
;
Wang, Wenjian
;
Zhu, Weiliang
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2019/01/08
BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis
期刊论文
CELLULAR & MOLECULAR IMMUNOLOGY, 2018, 卷号: 15, 期号: 12, 页码: 1047-1056
作者:
Zhou, Jinfeng
;
Lai, Weiming
;
Yang, Wanjie
;
Pan, Juping
;
Shen, Hu
收藏
  |  
浏览/下载:161/0
  |  
提交时间:2019/01/08
Gynura Rhizoma containing pyrrolizidine alkaloids induces the hepatic sinusoidal obstruction syndrome in mice via upregulating fibrosis-related factors
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Zhang, Fang
;
Zhou, Yue
;
Yang, Xiao
;
Xiong, Ai-Zhen
;
Wang, Zheng-Tao
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
SOMCL-085, a novel multi-targeted FGFR inhibitor, displays potent anticancer activity in FGFR-addicted human cancer models
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 243-250
作者:
Jiang, Xi-fei
;
Dai, Yang
;
Peng, Xia
;
Shen, Yan-yan
;
Su, Yi
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/01/08
human cancer
anticancer drug
SOMCL-085
receptor tyrosine kinase
FGFR
xenograft nude mouse model
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