Baicalin relaxes vascular smooth muscle and lowers blood pressure in spontaneously hypertensive rats

doi:10.1016/j.biopha.2018.12.086

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	Baicalin relaxes vascular smooth muscle and lowers blood pressure in spontaneously hypertensive rats
	Ding, Liliqiang 3,4; Jia, Chenglin 4; Zhang, Yong 1; Wang, Wenjian 2; Zhu, Weiliang1 ; Chen, Yu 2,4; Zhang, Teng 2,4
刊名	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
	2018-12-24
卷号	111 页码:325-330
ISSN号	1950-6007
DOI	10.1016/j.biopha.2018.12.086
文献子类	Article
英文摘要	Scutellaria baicalensis Georgi is an extensively used medicinal herb for the treatment of hypertension in traditional Chinese medicine. Baicalin is the most abundant flavone compound present in Scutellaria baicalensis Georgi and endothelium-dependent vascular activities of baicalin have been suggested. However, the pharmacological implications and mechanisms of baicalin under hypertensive conditions remain to be investigated. The current study examined the blood pressure-lowering effect of baicalin in a spontaneously hypertensive rat (SHR) model. Moreover, vascular activities and mechanisms of baicalin were investigated under hypertensive conditions. The results demonstrate that baicalin treatment lowers the blood pressure in SHRs in vivo. Ex vivo vascular reactivity assay reveals that baicalin relaxes phenylephrine (PE)-constricted SHR aortas in an endothelium-independent manner. Baicalin attenuates Angiotensin II (Ang II) or potassium chloride (KCl)-induced vasoconstriction in SHR aortas as well. Baicalin also relaxes SHR aortas in the presence of different Ca channel blockers such as nifedipine and SKF96365 in response to PE-induced constriction. Most importantly, ATP-sensitive potassium channel (K) blockade partially abrogated the vasorelaxant effect of baicalin. In summary, the current study demonstrates for the first time that intracellular Ca regulation in vascular smooth muscle is mechanistically implicated in the vasorelaxant effect of baicalin under hypertensive conditions. Furthermore, activated K channels are in part required for the vasorelaxant effect of baicalin under hypertensive conditions. Thus, the work here sheds novel pharmacological and mechanistic insights into the blood pressure-lowering effect of baicalin, which may help better understand the therapeutic application of Scutellaria baicalensis Georgi in the treatment of hypertension.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266825]
专题	药物发现与设计中心
通讯作者	Chen, Yu; Zhang, Teng
作者单位	1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 2.Clinical Research Institute of Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China 3.Clinical Research Institute of Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China; 4.Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;
推荐引用方式 GB/T 7714	Ding, Liliqiang,Jia, Chenglin,Zhang, Yong,et al. Baicalin relaxes vascular smooth muscle and lowers blood pressure in spontaneously hypertensive rats[J]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,2018,111:325-330.
APA	Ding, Liliqiang.,Jia, Chenglin.,Zhang, Yong.,Wang, Wenjian.,Zhu, Weiliang.,...&Zhang, Teng.(2018).Baicalin relaxes vascular smooth muscle and lowers blood pressure in spontaneously hypertensive rats.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,111,325-330.
MLA	Ding, Liliqiang,et al."Baicalin relaxes vascular smooth muscle and lowers blood pressure in spontaneously hypertensive rats".Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 111(2018):325-330.