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科研机构
上海药物研究所 [232]
内容类型
期刊论文 [232]
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2021 [13]
2020 [16]
2019 [12]
2018 [31]
2017 [31]
2016 [22]
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Chemistry [1]
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GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhang, Qing
;
Chen, Lin-hai
;
Yang, Hui
;
Fang, You-chen
;
Wang, Si-wei
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2022/01/18
GPR84
medium chain fatty acid receptor
GPCR
inflammatory bowel diseases
ulcerative colitis
NLRP3 inflammasome
macrophages
Impurity Identification and Scale-Up of a Novel Glycopeptide Antibiotic
期刊论文
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 卷号: 25, 期号: 11, 页码: 2390-2402
作者:
Jiao, Shang
;
Guan, Dongliang
;
Xu, Lili
;
Liu, Bo
;
Shi, Weiwei
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/01/18
glycopeptide antibiotics
impurity
analytical method
process optimization and development
Design, synthesis, and antibacterial evaluation of vancomycin-LPS binding peptide conjugates
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 45, 页码: 8
作者:
Shi, Weiwei
;
Chen, Feifei
;
Zou, Xiangman
;
Jiao, Shang
;
Wang, Siqi
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2021/08/17
Vancomycin analogues
LPS binding peptides
Vancomycin-Peptide Conjugates
Antibacterial activity
Synthesis and biological evaluation of novel cabazitaxel analogues
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 41, 页码: 12
作者:
Ren, Sumei
;
Zhang, Minmin
;
Wang, Yujie
;
Guo, Jia
;
Wang, Junfei
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2021/08/17
Tritium extraction
Hydrogen isotopes
Eutectic Pb-Li
Fusion fuel cycle
Cabazitaxel
Docetaxel
Taxel
Anticancer
Semi-synthesis
10-Deacetylbaccatin III
Cytotoxicity
Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8644-8665
作者:
Kong, Qidi
;
Pan, Wei
;
Xu, Heng
;
Xue, Yaru
;
Guo, Bin
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/08/17
Multi-omics characterization of WNT pathway reactivation to ameliorate BET inhibitor resistance in liver cancer cells
期刊论文
GENOMICS, 2021, 卷号: 113, 期号: 3, 页码: 1057-1069
作者:
Liu, Yuwei
;
Xue, Mengzhu
;
Cao, Danyan
;
Qin, Lihuai
;
Wang, Ying
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/08/17
Multi-omics
BET inhibitor responses
WNT pathway
Liver cancer
Precise therapy
Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers
期刊论文
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 9
作者:
Li, Meng-Zhu
;
Meng, Tao
;
Song, Shan-Shan
;
Bao, Xu-Bin
;
Ma, Lan-Ping
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/05/24
G-quadruplex stabilizer
MTR-106
BRCA-deficiency
PARP inhibitor
DNA damage
In Vivo Efficacy and Metabolism of the Antimalarial Cycleanine and Improved In Vitro Antiplasmodial Activity of Semisynthetic Analogues
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 卷号: 65, 期号: 2, 页码: 11
作者:
Uche, Fidelia Ijeoma
;
Guo, Xiaozhen
;
Okokon, Jude
;
Ullah, Imran
;
Horrocks, Paul
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
malaria
Plasmodium falciparum
Plasmodium berghei
bisbenzylisoquinoline alkaloids
cycleanine
metabolism
in vivo activity
antimalarial agents
drug metabolism
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 2, 页码: 488-504
作者:
Liu, Xiaohua
;
Zhang, Yu
;
Li, Yalei
;
Wang, Juan
;
Ding, Huaqian
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/05/24
Medulloblastoma
Hedgehog signaling
pathway
Drug resistance
GLI
BRD4
Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers
期刊论文
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 8
作者:
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Jiang, Jin-fang
;
Yang, Yong
;
Guo, Li-xia
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
Alflutinib
Rifampicin
CYP3A4
AST5902
Drug-drug interaction
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