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科研机构
上海药物研究所 [11]
内容类型
期刊论文 [11]
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2021 [2]
2019 [1]
2015 [2]
2014 [1]
2013 [3]
2004 [1]
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Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
Absorption, distribution, metabolism, and excretion of [C-14]NBP (3-n-butylphthalide) in rats
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1181, 页码: 9
作者:
Tian, Junjun
;
Lei, Peng
;
He, Yifei
;
Zhang, Ning
;
Ge, Xinyu
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/11/04
3-n-butylphthalide (NBP)
[C-14]NBP
Pharmacokinetics
Tissue distribution
Metabolism
Mass balance
New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites
期刊论文
FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 15
作者:
Diao, Xingxing
;
Huestis, Marilyn A.
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
novel psychoactive substances
NPS
synthetic cannabinoid
SC
metabolism
urinary metabolites
hepatocyte incubation
. Isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP and 10-hydroxy-NBP, across the rat blood-brain barrier
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 12, 页码: 1520-1527
作者:
Diao, Xing-xing
;
Zhong, Kan
;
Li, Xiu-li
;
Zhong, Da-fang
;
Chen, Xiao-yan
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
3-n-butylphthalide (NBP)
3-OH-NBP
10-OH-NBP
blood-brain barrier
isomer-selective
drug plasma protein binding
drug brain protein binding
P-gp/BCRP
cerebral ischemia
isomerselectivedistributionof3nbutylphthalidenbphydroxylatedmetabolites3hydroxynbpand10hydroxynbpacrosstheratbloodbrainbarrier
期刊论文
actapharmacologicasinica, 2015, 卷号: 36, 期号: 12, 页码: 1520
作者:
Diao Xingxing
;
Zhong Kan
;
Li Xiuli
;
Zhong Dafang
;
Chen Xiaoyan
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
CANCER RESISTANCE PROTEIN
P-GLYCOPROTEIN P-GP/ABCB1
TANDEM MASS-SPECTROMETRY
FOCAL CEREBRAL-ISCHEMIA
PLASMA-PROTEIN
CHIRAL 3-N-BUTYLPHTHALIDE
TISSUE DISTRIBUTION
DRUG DISCOVERY
BINDING
PENETRATION
3-n-butylphthalide (NBP)
3-OH-NBP
10-OH-NBP
blood-brain barrier
isomer-selective
drug plasma protein binding
drug brain protein binding
P-gp/BCRP
cerebral ischemia
Bioactivation of 3-n-Butylphthalide via Sulfation of Its Major Metabolite 3-Hydroxy-NBP: Mediated Mainly by Sulfotransferase 1A1
期刊论文
DRUG METABOLISM AND DISPOSITION, 2014, 卷号: 42, 期号: 4, 页码: 774-781
作者:
Diao, Xingxing
;
Pang, Xiaoyan
;
Xie, Cen
;
Guo, Zitao
;
Zhong, Dafang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Enantioselective determination of 3-n-butylphthalide (NBP) in human plasma by liquid chromatography on a teicoplanin-based chiral column coupled with tandem mass spectrometry
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2013, 卷号: 939, 页码: 67-72
作者:
Diao, Xingxing
;
Ma, Zhiyu
;
Lei, Peng
;
Zhong, Dafang
;
Zhang, Yifan
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
3-n-Butylphthalide (NBP)
Teicoplanin-based chiral column
LC-MS/MS
Enantioselective pharmacokinetics
Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC-MS/MS using deuterated internal standards
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2013, 卷号: 78-79, 页码: 19-26
作者:
Diao, Xingxing
;
Ma, Zhiyu
;
Wang, Haidong
;
Zhong, Dafang
;
Zhang, Yifan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
3-n-Butylphthalide (NBP)
Deuterated internal standard
LC-MS/MS
Pharmacokinetics
Negative-positive ionization switching
Metabolism and Pharmacokinetics of 3-n-Butylphthalide (NBP) in Humans: The Role of Cytochrome P450s and Alcohol Dehydrogenase in Biotransformation
期刊论文
DRUG METABOLISM AND DISPOSITION, 2013, 卷号: 41, 期号: 2, 页码: 430-444
作者:
Diao, Xingxing
;
Deng, Pan
;
Xie, Cen
;
Li, Xiuli
;
Zhong, Dafang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Recent pharmacological studies on natural products in China
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 卷号: 500, 期号: 1-3, 页码: 221-230
作者:
Zhu, XZ
;
Li, XY
;
Liu, J
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
natural product
huperzine A
s-(-)-3-n-butylphthalide
(-)-clausenamide
Ginkgo biloba extract
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