isomerselectivedistributionof3nbutylphthalidenbphydroxylatedmetabolites3hydroxynbpand10hydroxynbpacrosstheratbloodbrainbarrier

doi:10.1038/aps.2015.64

	isomerselectivedistributionof3nbutylphthalidenbphydroxylatedmetabolites3hydroxynbpand10hydroxynbpacrosstheratbloodbrainbarrier
	Diao Xingxing; Zhong Kan; Li Xiuli; Zhong Dafang; Chen Xiaoyan
刊名	actapharmacologicasinica
	2015
卷号	36 期号:12 页码:1520
关键词	CANCER RESISTANCE PROTEIN P-GLYCOPROTEIN P-GP/ABCB1 TANDEM MASS-SPECTROMETRY FOCAL CEREBRAL-ISCHEMIA PLASMA-PROTEIN CHIRAL 3-N-BUTYLPHTHALIDE TISSUE DISTRIBUTION DRUG DISCOVERY BINDING PENETRATION 3-n-butylphthalide (NBP) 3-OH-NBP 10-OH-NBP blood-brain barrier isomer-selective drug plasma protein binding drug brain protein binding P-gp/BCRP cerebral ischemia
ISSN号	1671-4083
DOI	10.1038/aps.2015.64
英文摘要	Aim: To investigate the mechanisms underlying the isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP (3-OH-NBP) and 10-hydroxy-NBP (10-OH-NBP), across the blood brain barrier (BBB).
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/285471]
专题	中国科学院上海药物研究所
作者单位	中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Diao Xingxing,Zhong Kan,Li Xiuli,et al. isomerselectivedistributionof3nbutylphthalidenbphydroxylatedmetabolites3hydroxynbpand10hydroxynbpacrosstheratbloodbrainbarrier[J]. actapharmacologicasinica,2015,36(12):1520.
APA	Diao Xingxing,Zhong Kan,Li Xiuli,Zhong Dafang,&Chen Xiaoyan.(2015).isomerselectivedistributionof3nbutylphthalidenbphydroxylatedmetabolites3hydroxynbpand10hydroxynbpacrosstheratbloodbrainbarrier.actapharmacologicasinica,36(12),1520.
MLA	Diao Xingxing,et al."isomerselectivedistributionof3nbutylphthalidenbphydroxylatedmetabolites3hydroxynbpand10hydroxynbpacrosstheratbloodbrainbarrier".actapharmacologicasinica 36.12(2015):1520.