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上海药物研究所 [35]
山东大学 [9]
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期刊论文 [105]
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Two New Cytotoxic Maytansinoids Targeting Tubulin from Trewia nudiflora
期刊论文
PLANTA MEDICA, 2021, 页码: 7
作者:
Lei, Chun
;
Li, Ya-Nan
;
Li, Jia-Nan
;
Zhou, Yu-Bo
;
Cui, Ming-Jun
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/12/16
Trewia nudiflora
Euphorbiaceae
maytansinoids
cytotoxicity
tubulin polymerization
Development of Taccalonolide AJ-Hydroxypropyl-beta-Cyclodextrin Inclusion Complexes for Treatment of Clear Cell Renal-Cell Carcinoma
期刊论文
MOLECULES, 2020, 卷号: 25, 期号: 23, 页码: 14
作者:
Han, Jing
;
Zhang, Siwang
;
Niu, Junxin
;
Zhang, Chunli
;
Dai, Weichen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
taccalonolide AJ
microtubule stabilizer
hydroxypropyl-β
-cyclodextrin
inclusion complex
clear-cell renal-cell carcinoma
Discovery of isopenicin A, a meroterpenoid as a novel inhibitor of tubulin polymerization
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020
作者:
Chen, Lin
;
Fan, Dong-Mei
;
Tang, Jian-Wei
;
An, Tao
;
Li, Xue
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/01/05
1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 448-456
作者:
Jiang, Junhang
;
Zhang, Hao
;
Wang, Chongqing
;
Zhang, Qingsen
;
Fang, Shaoyu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Microtubule-targeting agents
Colchicine site inhibitors
Cis-trans photoisomerization
X-ray co-crystal structure
Water-soluble prodrug
Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 7, 页码: 10
作者:
Zhang, Yu
;
Goto, Masuo
;
Oda, Akifumi
;
Hsu, Pei-Ling
;
Guo, Ling-Li
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2019/07/29
aspidosperma-type
monoterpenoid indole alkaloids
antiproliferative activity
tubulin inhibitor
Bousigonia mekongensis
Synthesis, biological evaluation and molecular docking of benzimidazole grafted benzsulfamide-containing pyrazole ring derivatives as novel tubulin polymerization inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 3
作者:
Shi, Tian-Qi
;
Wang, Yan-Ting
;
Liu, Chang-Hong
;
Zhu, Hai-Liang
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
Benzimidazole
Benzsulfamide
Pyrazole
Tubulin
Inhibition
Apoptosis
Molecular docking
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 178
作者:
Gao, Feng
;
Liang, Yuru
;
Zhou, Pengfei
;
Cheng, Jiayi
;
Ding, Kuiling
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/05
Imidazo[4,5-c]pyridin-2-one
Tubulin polymerization
Katanin
Antitumor
3, 9-di-O-substituted coumestrols incorporating basic amine side chains act as novel apoptosis inducers with improved pharmacological selectivity
期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 85
作者:
Luo, Guoshun
;
Tang, Zhengpu
;
Li, Xinyu
;
Hou, Qiangqiang
;
Chen, Yu
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/05
Coumestrol
Estrogenic activity
Apoptosis
Cell cycle
Tubulin polymerization inhibitor
3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.168, 页码: 426-435
作者:
Min'an Zhai
;
Shiyuan Liu
;
Meiqi Gao
;
Long Wang
;
Jun Sun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/12/13
Ring tethering
Conformational analysis
Pyrazolo[3,4-b]pyridine
Colchicine site
Tubulin colchicine site binding agent LL01 displays potent antitumor efficiency both in vitro and in vivo with suitable drug-like properties
期刊论文
Investigational New Drugs, 2019
作者:
Wu J.-D.
;
Cui Y.-J.
;
Zhou Y.-G.
;
Tang L.-Q.
;
Zhang C.-M.
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
Hepatocellular carcinoma
Liver microsome stability
Multidrug-resistance
Pharmacokinetics
Tubulin polymerization inhibitor
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