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科研机构
大连化学物理研究所 [6]
厦门大学 [1]
上海药物研究所 [1]
内容类型
期刊论文 [8]
发表日期
2021 [1]
2016 [1]
2014 [1]
2013 [2]
2012 [2]
2011 [1]
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物理化学 [1]
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Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Strong Specific Inhibition of UDP-glucuronosyltransferase 2B7 by Atractylenolide I and III
期刊论文
PHYTOTHERAPY RESEARCH, 2016, 卷号: 30, 期号: 1, 页码: 25-30
作者:
Cao, Yun-Feng
;
Ran, Rui-Xue
;
Li, Rong-Shan
;
Zhang, Qian
;
Wu, Xue
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/06/20
Atractylenolide i
Atractylenolide Iii
Drug-drug Interaction
Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7
期刊论文
toxicology and applied pharmacology, 2014, 卷号: 277, 期号: 1, 页码: 86-94
作者:
Ma, Hai-Ying
;
Sun, Dong-Xue
;
Cao, Yun-Feng
;
Ai, Chun-Zhi
;
Qu, Yan-Qing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2015/11/17
Andrographolide derivatives
Herb-drug interaction (HDI)
UDP-glucuronosyltransferases (UGTs)
Adverse effects
Structure-inhibition relationship of ginsenosides towards UDP-glucuronosyltransferases (UGTs)
期刊论文
toxicology and applied pharmacology, 2013, 卷号: 267, 期号: 2, 页码: 149-154
作者:
Fang, Zhong-Ze
;
Cao, Yun-Feng
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2015/11/09
Ginsenosides
UDP-glucuronosyltransferases (UGTs)
Ginseng-drug interaction
Isoliquiritigenin showed strong inhibitory effects towards multiple UDP-glucuronosyltransferase (UGT) isoform-catalyzed 4-methylumbelliferone (4-MU) glucuronidation
期刊论文
fitoterapia, 2013, 卷号: 84, 页码: 208-212
作者:
Lu, Hang
;
Fang, Zhong-Ze
;
Cao, Yun-Feng
;
Hu, Cui-Min
;
Hong, Mo
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  |  
浏览/下载:24/0
  |  
提交时间:2015/11/09
Isoliquiritigenin
UDP-glucuronosyltransferase (UGT)
Enzyme inhibition
Identification of CYP isoforms involved in the metabolism of thymol and carvacrol in human liver microsomes (HLMs)
期刊论文
pharmazie, 2012, 卷号: 67, 期号: 12, 页码: 1002-1006
作者:
Dong, Rui-Hua
;
Fang, Zhong-Ze
;
Zhu, Liang-Liang
;
Ge, Guang-Bo
;
Cao, Yun-Feng
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2015/11/13
Investigation of UDP-glucuronosyltransferases (UGTs) Inhibitory Properties of Carvacrol
期刊论文
phytotherapy research, 2012, 卷号: 26, 期号: 1, 页码: 86-90
作者:
Dong, Rui-Hua
;
Fang, Zhong-Ze
;
Zhu, Liang-Liang
;
Liang, Si-Cheng
;
Ge, Guang-Bo
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2013/10/11
UDP-glucuronosyltransferases (UGTs)
carvacrol
drug-drug interactions (DDIs)
Integrated Transcriptional and Proteomic Analysis with In Vitro Biochemical Assay Reveal the Important Role of CYP3A46 in T-2 Toxin Hydroxylation in Porcine Primary Hepatocytes
期刊论文
http://dx.doi.org/10.1074/mcp.M111.008748, 2011
Wang, Jianshe
;
Jiang, Jun
;
Zhang, Hongxia
;
Wang, Junping
;
Cai, Hua
;
Li, Cheng
;
Li, Kangbai
;
Liu, Jing
;
Guo, Xuejiang
;
Zou, Guangxun
;
Wang, Dazhi
;
Deng, Yiqun
;
Dai, Jiayin
;
王大志
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2013/12/12
DRUG-METABOLIZING-ENZYMES
HUMAN CYTOCHROME-P450 3A4
TANDEM MASS-SPECTROMETRY
TRICHOTHECENE MYCOTOXINS
MICROSOMAL DEACETYLATION
NATURAL OCCURRENCE
IMMUNE-RESPONSE
GENE-EXPRESSION
FUSARIUM TOXINS
LIVER
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