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上海药物研究所 [15]
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Rational design of a near-infrared fluorescence probe for highly selective sensing butyrylcholinesterase (BChE) and its bioimaging applications in living cell
期刊论文
TALANTA, 2020, 卷号: 219, 页码: 10
作者:
Ma, Jianlong
;
Lu, Xiaofeng
;
Zhai, Honglin
;
Li, Qiang
;
Qiao, Li
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/12/15
Fluorescent probe
Rational design
Highly selective
Butyrylcholinesterase
A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer's Disease
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21, 期号: 5, 页码: 19
作者:
Wu, Wenyong
;
Zhang, Zijia
;
Li, Feifei
;
Deng, Yanping
;
Lei, Min
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Uncaria alkaloids
network pharmacology
hypertension
Alzheimer's disease
butyrylcholinesterase
molecular docking
Discovery and Biological Evaluation of New Selective Acetylcholinesterase Inhibitors with Anti-A beta Aggregation Activity through Molecular Docking-Based Virtual Screening
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2020, 卷号: 68, 期号: 2, 页码: 161-166
作者:
Liu, Guangpu
;
Jiao, Yang
;
Lin, Yongqiang
;
Hao, Haifang
;
Dou, Yanli
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  |  
浏览/下载:53/0
  |  
提交时间:2020/07/01
selective acetylcholinesterase inhibitor
amyloid beta aggregation
neuroprotectant
molecular docking
molecular dynamics simulation
Rational design of a near-infrared fluorescence probe for highly selective sensing butyrylcholinesterase (BChE) and its bioimaging applications in living cell
期刊论文
Talanta, 2020, 期号: 219, 页码: 121278
作者:
Jianlong Ma
;
Xiaofeng Lu
;
Honglin Zhai
;
Qiang Li
;
Li Qiao
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/11/18
Near-Infrared Fluorescence Probe for Evaluating Acetylcholinesterase Activity in PC12 Cells and In Situ Tracing AChE Distribution in Zebrafish
期刊论文
ACS SENSORS, 2020, 卷号: 5, 期号: 1, 页码: 83-92
作者:
Ma, Jianlong
;
Si, Tiantian
;
Yan, Chaoxian
;
Li, Yijing
;
Li, Qiang
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/01/19
fluorescence probes
near-infrared
zebrafish
bioimaging
in situ
acetylcholinesterase
Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2019, 卷号: 82, 期号: 12, 页码: 3221-3226
作者:
Hong, Wei
;
Zhang, Yu
;
Yang, Jun
;
Xia, Meng-Yuan
;
Luo, Ji-Feng
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/03/18
Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-A beta Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 14, 页码: 21
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Wang, Yin-Yin
;
Tao, Hong-Rui
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
selective BChE inhibitor
virtual screening
structural optimization
molecular dynamics
anti-A beta aggregation
Pharmacophore-based drug design for the identification of novel butyrylcholinesterase inhibitors against Alzheimer's disease
期刊论文
PHYTOMEDICINE, 2019, 卷号: 54, 期号: 2, 页码: 278-290
作者:
Jiang, YY (Jiang, Yingying)[ 2 ]
;
Gao, HW (Gao, Hongwei)[ 1,2 ]
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2019/03/19
Alzheimer's disease (AD)
Butyrylcholinesterase (BChE)
Flavonoids
Pharmacophore models
Molecular docking
De novo evolution
Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors
期刊论文
DRUG DISCOVERY TODAY, 2019, 卷号: 24, 期号: 2, 页码: 629-635
作者:
Jing, Lanlan
;
Wu, Gaochan
;
Kang, Dongwei
;
Zhou, Zhongxia
;
Song, Yuning
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/11
Structure-activity study of fluorine or chlorine-substituted cinnamic acid derivatives with tertiary amine side chain in acetylcholinesterase and butyrylcholinesterase inhibition
期刊论文
DRUG DEVELOPMENT RESEARCH, 2019, 卷号: Vol.80 No.4, 页码: 438-445
作者:
Gao, XH
;
Tang, JJ
;
Liu, HR
;
Liu, LB
;
Liu, YZ
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/17
cholinesterase inhibitors
cinnamic acid
halogen
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