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科研机构
上海药物研究所 [6]
厦门大学 [1]
昆明植物研究所 [1]
动物研究所 [1]
兰州化学物理研究所 [1]
内容类型
期刊论文 [10]
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2022 [1]
2018 [2]
2015 [4]
2013 [1]
2011 [1]
2008 [1]
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(-)-Naringenin 4’,7-Dimethyl Ether Isolated from Nardostachys jatamansi Relieves Pain Through Inhibition of Multiple Channels
期刊论文
Molecules, 2022, 卷号: 5, 期号: 27, 页码: 1735
作者:
Ru-Rong Gu
;
Xian-Hua Meng
;
Yin Zhang
;
Hai-Yan Xu
;
Li Zhan
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2022/11/30
(-)-Naringenin 40,7-dimethyl ether
analgesic candidate
mechanism study
delayed rectifier potassium currents
ion channels
Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 4, 页码: 587-596
作者:
Zheng, Yue-ming
;
Wang, Wan-fu
;
Li, Yan-fen
;
Yu, Yong
;
Gao, Zhao-bing
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  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
Nav1.7 channels
analgesics
CNV1014802
inactivated state
paroxysmal extreme pain disorder
Anticancer efficiency of cycloartane triterpenoid derivatives isolated from Cimicifuga yunnanensis Hsiao on triple-negative breast cancer cells
期刊论文
CANCER MANAGEMENT AND RESEARCH, 2018, 卷号: 10, 页码: 6715-6729
作者:
Li, Xiao
;
Wang, Wei
;
Fan, Yi
;
Wei, Yue
;
Yu, Li-Qin
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  |  
浏览/下载:26/0
  |  
提交时间:2019/03/29
Design, synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel mu opioid receptor ligands
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 7, 页码: 887-894
作者:
Shen, Qing
;
Qian, Yuan-yuan
;
Xu, Xue-jun
;
Li, Wei
;
Liu, Jing-gen
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
mu-opioid receptor
tramadol
morphine
molecular docking
Discovery, stereospecific characterization and peripheral modification of 1-(pyrrolidin-1-ylmethyl)-2-[(6-chloro-3-oxo-indan)-formyl]-1,2,3,4-tetrahydroisoquinolines as novel selective kappa opioid receptor agonists
期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 卷号: 13, 期号: 20, 页码: 5656-5673
作者:
Gan, Zong-Jie
;
Wang, Yu-Hua
;
Xu, Yun-Gen
;
Guo, Ting
;
Wang, Jun
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  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
designsynthesisandbiologicalevaluationofnphenylalkylsubstitutedtramadolderivativesasnovelopioidreceptorligands
期刊论文
actapharmacologicasinica, 2015, 卷号: 36, 期号: 7, 页码: 887
作者:
Shen Qing
;
Qian Yuanyuan
;
Xu Xuejun
;
Li Wei
;
Liu Jinggen
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
μ-opioid receptor
tramadol
morphine
molecular docking
Design,synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands
期刊论文
Acta Pharmacologica Sinica, 2015, 卷号: 36, 期号: 7, 页码: 887
作者:
Shen Qing
;
Qian Yuanyuan
;
Xu Xuejun
;
Li Wei
;
Liu Jinggen
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/12/24
μ-opioid receptor
tramadol
morphine
molecular docking
Heterocycle-linked Phenylbenzyl Amides as Novel TRPV1 Antagonists and Their TRPV1 Binding Modes: Constraint-Induced Enhancement of In Vitro and In Vivo Activities
期刊论文
http://dx.doi.org/10.1002/asia.201200730, 2013
Kim, Nam-Jung
;
Li, Fu-Nan
;
Lee, Jin Hee
;
Park, Seul-gi
;
Kim, Kyeojin
;
Lim, Changjin
;
Han, Young Taek
;
Yun, Hwayoung
;
Jung, Jong-Wha
;
Park, Hyeung-geun
;
Kim, Hee-Doo
;
Woo, Byoung Young
;
Shin, Song Seok
;
Kim, Sun-Young
;
Choi, Jin Kyu
;
Jeong, Yeon-Su
;
Pa
;
李福男
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2015/07/22
VANILLOID RECEPTOR-1 ANTAGONISTS
CAPSAICIN RECEPTOR
BIOLOGICAL EVALUATION
IMPROVED SOLUBILITY
CLINICAL CANDIDATE
DISCOVERY
POTENT
PAIN
ANALOGS
DESIGN
DrTx(1-42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs
期刊论文
Biochemical Pharmacology, 2011, 卷号: 81, 期号: 3, 页码: 425-431
Zhu SY
;
Luo L
;
Li P
;
Gao B
;
Zhu LM
;
Yuan YZ
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  |  
浏览/下载:3/0
  |  
提交时间:2015/07/08
Synthesis and central none-opioid analgesic activity of SIPI5047
期刊论文
Acta Pharmaceutica Sinica, 2008, 卷号: 43, 期号: 6, 页码: 611-618
作者:
LI Jianqi
;
HUANG Liying
;
CHEN Xinjian
;
WENG Zhijie
;
ZHANG Chunnian
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
SIPI5047
SIPI5047
synthesis
central none-opioid analgesic agent
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