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Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13
作者:
Chen, Yun
;
Bai, Gang
;
Li, Yan
;
Ning, Yi
;
Cao, Sufen
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/12/01
FLT3
FLT3-ITD
Acute myeloid leukemia
Structure-activity relationships
Pyrazolo[1, 5-a]pyrimidine
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:
Liu, Xiao
;
Jiang, Shuang
;
Kong, Linghui
;
Ye, Rongrong
;
Xiao, Li
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  |  
浏览/下载:110/0
  |  
提交时间:2021/05/24
Morphinans
arylacetamidyl substituent
kappa opioid receptor modulators
structure-activity relationships
Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity
期刊论文
MOLECULES, 2021, 卷号: 26, 期号: 1, 页码: 11
作者:
Ji, Hong-Jian
;
Li, Jia-Yuan
;
Wu, Shi-Fei
;
Wu, Wen-Yong
;
Yao, Chang-Liang
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  |  
浏览/下载:34/0
  |  
提交时间:2021/05/24
Aristolochia contorta
aristolochic acid
cytotoxicity
molecular docking
Isolation and structure elucidation of polysaccharides from fruiting bodies of mushroom Coriolus versicolor and evaluation of their immunomodulatory effects
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 卷号: 166, 页码: 1387-1395
作者:
Zhang, Xue
;
Cai, Zhenyu
;
Mao, Haoyu
;
Hu, Pei
;
Li, Xiaojun
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  |  
浏览/下载:39/0
  |  
提交时间:2021/05/24
Coriolus versicolor
Polysaccharides
Chemical structure
NMR analysis
Methylation
Immunoregulatory effects
Beta-glucan
Design, synthesis and anti-tumor activities of carbamate derivatives of cinobufagin
期刊论文
STEROIDS, 2020, 卷号: 164, 页码: 11
作者:
Zhou, Yang
;
Hou, Jinjun
;
Long, Huali
;
Zhang, Zijia
;
Lei, Min
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  |  
浏览/下载:41/0
  |  
提交时间:2021/05/24
Cardiac glycosides
Cinobufagin
Natural product
Cytotoxicity
Antiproliferative activities
Soil extracellular enzyme stoichiometry reflects the shift from P- to N-limitation of microorganisms with grassland restoration
期刊论文
SOIL BIOLOGY & BIOCHEMISTRY, 2020, 卷号: 149, 页码: 8
作者:
Yang, Yang
;
Liang, Chao
;
Wang, Yunqiang
;
Cheng, Huan
;
An, Shaoshan
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  |  
浏览/下载:88/0
  |  
提交时间:2020/12/29
Extracellular enzyme activity
Microbial biomass
Nutrient limitation
Restoration ecology
Vector analysis
Synthesis of triazolotriazine derivatives as c-Met inhibitors
期刊论文
MOLECULAR DIVERSITY, 2020, 页码: 8
作者:
Guo, Yuting
;
Peng, Xia
;
Ji, Yinchun
;
Zhang, Yitong
;
Ding, Jian
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/12/24
Receptor tyrosine kinase
c-Met
Triazolotriazine
SAR
Cellular potency
Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma
期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 93, 页码: 10
作者:
Wei, Wen-Jun
;
Qi, Weiyan
;
Gao, Xin-Mei
;
Feng, Ke-Na
;
Ma, Kai-Liang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/03/18
Euphorbia hylonoma
ent-Isopimarane
ent-Rosane
Anti-inflammatory
Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure-activity relationships
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3299-3306
作者:
Chen, Si-Yue
;
Geng, Chang-An
;
Ma, Yun-Bao
;
Huang, Xiao-Yan
;
Yang, Xiao-Tong
收藏
  |  
浏览/下载:139/0
  |  
提交时间:2019/09/10
Gastrodia elata
Polybenzyls
Melatonin receptors
Structure-activity relationships
Docking study
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