Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity

doi:10.3390/molecules26010044

	Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity
	Ji, Hong-Jian 1,2,3; Li, Jia-Yuan 1; Wu, Shi-Fei 1; Wu, Wen-Yong 2; Yao, Chang-Liang 1; Yao, Shuai 1; Zhang, Jian-Qing 1; Guo, De-An 1,2
刊名	MOLECULES
	2021
卷号	26 期号:1 页码:11
关键词	Aristolochia contorta aristolochic acid cytotoxicity molecular docking
DOI	10.3390/molecules26010044
通讯作者	Guo, De-An(daguo@simm.ac.cn)
英文摘要	Twelve compounds, including two new aristolochic acid analogues with a formyloxy moiety (9-10) and 10 known aristolochic acid derivates (1-8 and 11-12), were obtained from the roots of Aristolochia contorta. Their structures were elucidated using extensive spectroscopic methods. Their cytotoxic activity in human proximal tubular cells HK-2 was evaluated by the MTT method, which has been widely used to assess cell viability. Among these molecules, compounds 3 and 9 were found to be more cytotoxic. Furthermore, molecular modeling was used to evaluate, for the first time, the interactions of compounds 3 and 9 with the target protein organic anionic transporter 1 (OAT1) that plays a key role in mediating aristolochic acid nephropathy. Structure-activity relationships are briefly discussed.
资助项目	Jiangsu Provincial Commission of Health and Family Planning, China[QNRC2016465]
WOS关键词	CONSTITUENTS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000606223200001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296104]
专题	中国科学院上海药物研究所
通讯作者	Guo, De-An
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Xianlin Rd 138, Nanjing 210023, Peoples R China 3.Nanjing Med Univ, Yancheng Sch Clin Med, Dept Pharm, Yancheng 224001, Peoples R China
推荐引用方式 GB/T 7714	Ji, Hong-Jian,Li, Jia-Yuan,Wu, Shi-Fei,et al. Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity[J]. MOLECULES,2021,26(1):11.
APA	Ji, Hong-Jian.,Li, Jia-Yuan.,Wu, Shi-Fei.,Wu, Wen-Yong.,Yao, Chang-Liang.,...&Guo, De-An.(2021).Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity.MOLECULES,26(1),11.
MLA	Ji, Hong-Jian,et al."Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity".MOLECULES 26.1(2021):11.