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上海药物研究所 [145]
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
A highly sensitive colorimetric sensing platform based on silver nanocomposites for alkaline phosphatase
期刊论文
Analytical Methods, 2022, 期号: 14, 页码: 2431-2438
作者:
Wei-Feng Wang
;
Stanislas Nsanzamahoro
;
Ying Zhang
;
Cheng-Bo Wang
;
Yan-Ping Shi
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2022/11/30
Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:
Zhang, Chun
;
Sun, Yi-Tao
;
Gao, Li-Xin
;
Feng, Bo
;
Yan, Xue
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/01/18
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel N-Acylhydrazone Derivatives Containing Carbazole and Aromatic Ring/Aromatic Fused Heterocycle
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 9, 页码: 3593-3607
作者:
Li Yingjun
;
Lin Ledi
;
Liu Jihong
;
Gao Lixin
;
Sheng Li
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/12/01
PTP1B inhibitor
carbazole
N-actylhydrazone
synthesis
molecular docking
Rearranged Diels-Alder Adducts and Prenylated Flavonoids as Potential PTP1B Inhibitors from Morus nigra
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2021, 卷号: 84, 期号: 8, 页码: 2303-2311
作者:
Qu, Ke-Jun
;
Wang, Bin
;
Jiang, Chang-Sheng
;
Xie, Bao-Gang
;
Liu, Ai-Hong
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/11/04
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:
Yu Lijie
;
Feng Bo
;
Wang Zhijia
;
Gao Lixin
;
Zhang Chun
收藏
  |  
浏览/下载:187/0
  |  
提交时间:2021/11/04
5-phenyl-1,3,4-thiadiazole derivatives
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)
inhibitors
structure-activity relationships
Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel Arylaminoacetylhydrazone Derivatives Containing Carbazole Moiety
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3157-3170
作者:
Li Yingjun
;
Lin Ledi
;
Jin Kun
;
Gao Lixin
;
Sheng Li
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/11/04
protein tyrosine phosphatase 1B (PTP1B) inhibitor
carbazole
arylaminoacetylhydrazone
synthesis
molecular docking
Discovery of 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 13
作者:
Jiang, Bo
;
Luo, Jiao
;
Guo, Shuju
;
Wang, Lijun
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/05/11
Type 2 diabetes mellitus
Protein tyrosine phosphatase 1B inhibitors
Thiazolidinedione
Insulin signaling
Anti-diabetic activities
Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent gamma-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B
期刊论文
RSC ADVANCES, 2021, 卷号: 11, 期号: 6, 页码: 3216-3220
作者:
Mu, Xu-Yang
;
Wang, Zhi-Jia
;
Feng, Bo
;
Xu, Lei
;
Gao, Li-Xin
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/05/24
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