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科研机构
上海药物研究所 [3]
湖南大学 [2]
南海海洋研究所 [1]
中南大学 [1]
复旦大学上海医学院 [1]
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期刊论文 [7]
会议论文 [1]
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2021 [1]
2019 [2]
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2014 [1]
2013 [2]
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New PCSK9 inhibitor miR-552-3p reduces LDL-C via enhancing LDLR in high fat diet-fed mice
期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 167, 页码: 13
作者:
Ma, Ningning
;
Fan, Lei
;
Dong, Yunxia
;
Xu, Xiaoding
;
Yu, Chuwei
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/08/17
PCSK9
Hyperlipidemia
MiR-552-3p
3 '-UTR
Promoter
Small molecules as inhibitors of PCSK9: Current status and future challenges
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.162, 页码: 212-233
作者:
Shengtao Xu
;
Shanshan Luo
;
Zheying Zhu
;
Jinyi Xu
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/13
PCSK9
protein
Inhibitor
Small-molecule
LDL-C
Hypercholesterolemia
Natural
products
Patent
Small molecules as inhibitors of PCSK9: Current status and future challenges
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: Vol.162, 页码: 212-233
作者:
Xu, Shengtao
;
Luo, Shanshan
;
Zhu, Zheying
;
Xu, Jinyi
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/17
PCSK9 protein
Inhibitor
Small-molecule
LDL-C
Hypercholesterolemia
Natural products
Patent
Rationale and design of a randomized study to assess the efficacy and safety of evolocumab in patients with diabetes and dyslipidemia: The BERSON clinical trial
期刊论文
CLINICAL CARDIOLOGY, 2018, 卷号: 41, 期号: 9
作者:
Lorenzatti, Alberto J.
;
Eliaschewitz, Freddy G.
;
Chen, Yundai
;
Fialkow, Jonathan
;
Lu, Juming
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
diabetes
diabetic dyslipidemia
dyslipidemia
hypercholesterolemia
monoclonal antibody
PCSK9
PCSK9 inhibitor
Two proprotein convertase subtilisin/kexin type 9 (PCSK9) paralogs from the tropical sea cucumber (Stichopus monotuberculatus): Molecular characterization and inducible expression with immune challenge
期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2016, 卷号: 56, 页码: 255-262
作者:
Ren, Chunhua
;
Chen, Ting
;
Jiang, Xiao
;
Sun, Hongyan
;
Qian, Jing
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2016/12/22
Proprotein convertase subtilisin/kexin type 9
Stichopus monotuberculatus
cDNA
Gene structure
Innate immune defense
MG132, a proteasome inhibitor, enhances LDL uptake in HepG2 cells in vitro by regulating LDLR and PCSK9 expression
期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 8, 页码: 994-1004
作者:
Yan, Hong
;
Ma, Yan-ling
;
Gui, Yu-zhou
;
Wang, Shu-mei
;
Wang, Xin-bo
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
cholesterol homeostasis
LDLR
MG132
proteasome inhibition
PKC
PCSK9
pravastatin
HepG2
cells
The proteasome inhibitor MG132 enhances LDL uptake in hepatocytes through regulating LDLR and PCSK9 expression: a novel role in cholesterol homeostasis
会议论文
作者:
Yan, Hong
;
Ma, Yan-ling
;
Wang, Xin-bo
;
Gui, Yu-zhou
;
Gao, Fei
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Low-density lipoprotein receptor
proprotein convertase subtilisin/kexin type 9
protein kinase C
hamster
The next generation of novel low-density lipoprotein cholesterol-lowering agents: Proprotein convertase subtilisin/kexin 9 inhibitors
期刊论文
Pharmacological Research, 2013, 卷号: 73, 页码: 27-34
作者:
Shen, Li
;
Peng, Hongchun
;
Xu, Danyan*
;
Zhao, Shuiping
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
Proprotein convertase subtilisin/kexin 9
LDL receptor
LDL cholesterol
Gain-of-function mutation
PCSK9 inhibitor
Dyslipidemia
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