CORC

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CORC

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Pharmacokinetics, mass balance, and metabolism of [C-14]vicagrel, a novel irreversible P2Y(12) inhibitor in humans 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:  Zheng, Yuan-dong;  Zhang, Hua;  Zhan, Yan;  Bian, Yi-cong;  Ma, Sheng
收藏  |  浏览/下载：41/0  |  提交时间：2021/05/24
Update of P2Y receptor pharmacology: IUPHAR Review 27 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 11, 页码: 2413-2433
作者:  Jacobson, Kenneth A.;  Delicado, Esmerilda G.;  Gachet, Christian;  Kennedy, Charles;  von Kuegelgen, Ivar
收藏  |  浏览/下载：60/0  |  提交时间：2020/07/01
Optimization of P2Y(12) Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbarnoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 6, 页码: 3088-3106
作者:  Kong, Deyu;  Xue, Tao;  Guo, Bin;  Cheng, Jianjun;  Liu, Shunyin
收藏  |  浏览/下载：13/0  |  提交时间：2020/07/01
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y(12) inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing 期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 127, 页码: 151-160
作者:  Li, Cai;  Zhang, Yifan;  Chen, Weili;  Lu, Youming;  Li, Wei
收藏  |  浏览/下载：101/0  |  提交时间：2019/01/08
Chinese patients carrying two CYP2C19 LOFs have a more active state of P2Y(12)-G(i) signaling and larger MPV in post-clopidogrel platelets with acute coronary syndrome 期刊论文
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 卷号: 12, 期号: 7
作者:  Xu, Huajie;  Wu, Hongyi;  Zhao, Xin;  Zhang, Yan;  Chen, She
收藏  |  浏览/下载：18/0  |  提交时间：2019/12/05
CYP2C19  clopidogrel  P2Y(12)  VASP  Akt  MPV  
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y(12) inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing 期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 127
作者:  Liu, Cai;  Zhang, Yifan;  Chen, Weili;  Lu, Youming;  Li, Wei
收藏  |  浏览/下载：26/0  |  提交时间：2019/12/05
P2Y(12) deficiency in mouse impairs noradrenergic system in brain, and alters anxiety-like neurobehavior and memory 期刊论文
GENES BRAIN AND BEHAVIOR, 2019, 卷号: 18, 期号: 2
作者:  Zheng, F.;  Zhou, Q.;  Cao, Y.;  Shi, H.;  Wu, H.
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/05
Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y(1) receptor antagonists 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 302-310
作者:  Peng, Jingjing;  Zhao, Lifen;  Wang, Lanlan;  Chen, Hui;  Qiu, Yunguang
收藏  |  浏览/下载：46/0  |  提交时间：2019/01/08
3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 18, 页码: 8136-8154
作者:  Baqi, Younis;  Pillaiyar, Thanigaimalai;  Abdelrahman, Aliaa;  Kaufmann, Olesja;  Aishaibani, Samer
收藏  |  浏览/下载：105/0  |  提交时间：2019/01/08
Dynamic States of the Ligand-Free Class A G Protein-Coupled Receptor Extracellular Side 期刊论文
BIOCHEMISTRY, 2018, 卷号: 57, 期号: 32, 页码: 4767-4775
作者:  Zhang, Qiansen;  Zhou, Mang;  Zhao, Lifen;  Jiang, Hualiang;  Yang, Huaiyu
收藏  |  浏览/下载：24/0  |  提交时间：2019/01/08

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