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Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 37, 页码: 16
作者:
Yang, Gui-Xiang
;
Sun, Jia-Min
;
Zheng, Lu-Lu
;
Zhang, Li
;
Li, Jie
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2021/06/11
Vascular dementia
Diosgenin
Antioxidant
Anti-cholinesterase
Multi-target-directed ligands
Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer's disease
期刊论文
PHYTOCHEMISTRY, 2019, 卷号: 157, 期号: x, 页码: 82-91
作者:
Xia, Chun-Li
;
Tang, Gui-Hua
;
Guo, Yan-Qiong
;
Xu, You-Kai
;
Huang, Zhi-Shu
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  |  
浏览/下载:65/0
  |  
提交时间:2019/04/22
Neurodegenerative Diseases
Directed Ligands
Tree
Constituents
Design
Derivatives
Flavonoids
Decade
Target
Beta
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 183, 页码: 111737
作者:
Bai, Ping
;
Wang, Keren
;
Zhang, Pengfei
;
Shi, Jian
;
Cheng, Xinfeng
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2021/11/04
Alzheimer's disease
Chalcone-O-Alkylamine derivatives
Multi-functional agents
Rational design
Synthesis
Precognitive effect
Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates
期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 138, 页码: 738-747
作者:
Zhao, Xiong-jie
;
Gong, Da-min
;
Jiang, Yu-ren*
;
Guo, Dong
;
Zhu, Yao
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  |  
浏览/下载:56/0
  |  
提交时间:2019/12/03
Alzheimer's disease
Acetylcholinesterase
β-secretase
Metal chelators
Inhibitor
AChE
acetylcholinesterase
AChEIs
acetylcholinesterase inhibitors
Aβ
β-amyloid
AD
Alzheimer's disease
PAS
peripheral anionic sites
BACE-1
β-secretase
MTDLs
multi-target-directed ligands
PDB
Protein Data Bank
TLC
thin layer chromatography
(-)-Meptazinol-melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-beta aggregation with high antioxidant potency for Alzheimer's therapy
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 13
作者:
Cheng, Shaobing
;
Zheng, Wei
;
Gong, Ping
;
Zhou, Qiang
;
Xie, Qiong
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  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Alzheimer's disease
Multi-target-directed ligands
A beta aggregation
Antioxidant
(-)-Meptazinol-melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-beta aggregation with high antioxidant potency for Alzheimer's therapy
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 13
作者:
Cheng, Shaobing
;
Zheng, Wei
;
Gong, Ping
;
Zhou, Qiang
;
Xie, Qiong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/19
Alzheimer's disease
Multi-target-directed ligands
A beta aggregation
Antioxidant
In-Silico Approaches to Multi-target Drug Discovery
期刊论文
2010
Ma, X. H.
;
Shi, Z.
;
Tan, C. Y.
;
Jiang, Y. Y.
;
Go, M. L.
;
Low, B. C.
;
Chen, Y. Z.
;
施展
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  |  
浏览/下载:2/0
  |  
提交时间:2013/12/12
computer aided dug design
multiple ligands
multi-target
multi-target drug discovery
virtual screening
Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 卷号: 17, 期号: 4, 页码: 1600-1613
作者:
Zhu, Yiping
;
Xiao, Kun
;
Ma, Lanping
;
Xiong, Bin
;
Fu, Yan
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
AD
AChE
BACE-1
Dual inhibitor
HE
HMC
HEA
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