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科研机构
上海药物研究所 [9]
内容类型
期刊论文 [8]
会议论文 [1]
发表日期
2018 [1]
2016 [2]
2014 [2]
2013 [3]
2008 [1]
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A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Bai, Fang
;
Pi, Xiaoping
;
Li, Ping
;
Zhou, Pingzheng
;
Yang, Huaiyu
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
KCNQ2 potassium channel
hill equation
thermodynamic model
patch clamp electrophysiology
activators
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 1, 页码: 105-110
作者:
Yue, Jin-feng
;
Qiao, Guan-hua
;
Liu, Ni
;
Chen, Xue-qin
;
Nan, Fa-jun
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
KCNQ2
channel activator
high-throughput screening
thallium flux assay
automated patch-clamp
ZG1732
ZG2083
Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clampbased high-throughput screening techniques
期刊论文
Acta Pharmacologica Sinica, 2016, 卷号: 37, 期号: 1, 页码: 105
作者:
Yue Jinfeng
;
Qiao Guanhua
;
Liu Ni
;
Chen Xueqin
;
Nan Fajun
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
POTASSIUM CHANNEL
KV7 CHANNELS
EPILEPSY
IDENTIFICATION
GENE
KCNQ2
channel activator
high-throughput screening
thallium flux assay
automated patch-clamp
ZG1732
ZG2083
The Human Ether-A-Go-Go-Related Gene Activator NS1643 Enhances Epilepsy-Associated KCNQ Channels
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2014, 卷号: 351, 期号: 3, 页码: 596-604
作者:
Li, Ping
;
Chen, Xueqin
;
Zhang, Qiansen
;
Zheng, Yueming
;
Jiang, Hualiang
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
An Activator Binding Site in the Gating Charge Pathway of KCNQ2 Channel
会议论文
作者:
Li, Ping
;
Chen, Zhuxi
;
Yang, Huaiyu
;
Gao, Zhaobing
;
Jiang, Hualiang
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels
期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 10, 页码: 1359-1366
作者:
Hu, Hai-ning
;
Zhou, Ping-zheng
;
Chen, Fei
;
Li, Min
;
Nan, Fa-jun
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
KCNQ2 channel
retigabine
HN38
XE991
structure modification
CHO cell
whole-cell recording
The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands
期刊论文
CELL RESEARCH, 2013, 卷号: 23, 期号: 9, 页码: 1106-1118
作者:
Li, Ping
;
Chen, Zhuxi
;
Xu, Haiyan
;
Sun, Haifeng
;
Li, Hao
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
voltage-gated potassium channel
gating charge pathway
KCNQ2 activator
binding site
anti-epilepsy drug
The ethylene bis-dithiocarbamate fungicide Mancozeb activates voltage-gated KCNQ2 potassium channel
期刊论文
TOXICOLOGY LETTERS, 2013, 卷号: 219, 期号: 3, 页码: 211-217
作者:
Li, Ping
;
Zhu, Jin
;
Kong, Qingya
;
Jiang, Baifeng
;
Wan, Xia
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Mancozeb
Fungicide
KCNQ2 channel
Ethylene bis-dithiocarbamates
Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 卷号: 105, 期号: 8, 页码: 3128-3133
作者:
Xiong, Qiaojie
;
Sun, Haiyan
;
Zhang, Yangming
;
Nan, Fajun
;
Li, Min
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
channel opener
epilepsy
genetic mutants
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