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CORC

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Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 216, 页码: 20
作者:  Gao, Dingding;  Jin, Nan;  Fu, Yixian;  Zhu, Yueyue;  Wang, Yujie
收藏  |  浏览/下载：40/0  |  提交时间：2021/06/11
A novel phosphoramide compound, DCZ0847, displays in vitro and in vivo anti-myeloma activity, alone or in combination with bortezomib 期刊论文
CANCER LETTERS, 2020, 卷号: 478, 页码: 45-55
作者:  Chen, Gege;  Hu, Ke;  Sun, Haiguo;  Zhou, Jinfeng;  Song, Dongliang
收藏  |  浏览/下载：91/0  |  提交时间：2020/07/01
A novel silicone derivative of natural osalmid (DCZ0858) induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway 期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 卷号: 5, 期号: 1, 页码: 11
作者:  Lu, Kang;  Li, Bo;  Zhang, Hui;  Xu, Zhijian;  Song, Dongliang
收藏  |  浏览/下载：55/0  |  提交时间：2020/07/01
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells 期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:  Shan, Hui;  Yao, Sheng;  Ye, Yang;  Yu, Qiang
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/01
Xanthatin inhibits STAT3 and NF-kappa B signalling by covalently binding to JAK and IKK kinases 期刊论文
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 卷号: 23, 期号: 6, 页码: 4301-4312
作者:  Liu, Man;  Xiao, Cheng-qian;  Sun, Ming-wei;  Tan, Min-jia;  Hu, Li-hong
收藏  |  浏览/下载：7/0  |  提交时间：2020/07/01
Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 8, 页码: 3898-3923
作者:  Liang, Xuewu;  Zang, Jie;  Li, Xiaoyang;  Tang, Shuai;  Huang, Min
收藏  |  浏览/下载：18/0  |  提交时间：2020/07/01
Discovery and evaluation of ZT55, a novel highly-selective tyrosine kinase inhibitor of JAK2 V617F against myeloproliferative neoplasms 期刊论文
Journal of Experimental and Clinical Cancer Research, 2019, 卷号: 38, 期号: 1
作者:  Hu M.;  Xu C.;  Yang C.;  Zuo H.;  Chen C.
收藏  |  浏览/下载：16/0  |  提交时间：2019/12/11
Discovery and evaluation of ZT55, a novel highly-selective tyrosine kinase inhibitor of JAK2(V617F) against myeloproliferative neoplasms 期刊论文
2019, 卷号: 38, 期号: 1, 页码: 49
作者:  Hu, Min;  Xu, Chengbo;  Yang, Chao;  Zuo, Hongli;  Chen, Chengjuan
收藏  |  浏览/下载：3/0  |  提交时间：2020/01/03
Discovery of novel selective Janus kinase 2 (JAK2) inhibitors bearing a 1H-pyrazolo[3,4-d]pyrimidin-4-amino scaffold 期刊论文
2019, 卷号: 27, 期号: 8, 页码: 1562-1576
作者:  Yin, Yuan;  Chen, Cheng-Juan;  Yu, Ru-Nan;  Shu, Lei;  Zhang, Tian-Tai
收藏  |  浏览/下载：3/0  |  提交时间：2020/01/03
3deoxy216dihydroxynagilactoneeanaturalcompoundfrompodocarpusnagipreferentiallyinhibitsjak2stat3signalingbyallostericallyinteractingwiththeregulatorydomainofjak2andinducesapoptosisofcancercells 期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 12, 页码: 1578
作者:  Shan Hui;  Yao Sheng;  Ye Yang;  Yu Qiang
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01

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