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期刊论文 [17]
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浏览/检索结果:
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IL6 blockade potentiates the anti-tumor effects of gamma-secretase inhibitors in Notch3-expressing breast cancer
期刊论文
CELL DEATH AND DIFFERENTIATION, 2018, 卷号: 25, 期号: 2
作者:
Wang, Dong
;
Xu, Jiahui
;
Liu, Bingjie
;
He, Xueyan
;
Zhou, Lei
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
Amyloid beta: structure, biology and structure-based therapeutic development
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 9, 页码: 1205-1235
作者:
Chen, Guo-fang
;
Xu, Ting-hai
;
Yan, Yan
;
Zhou, Yu-ren
;
Jiang, Yi
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
amyloid beta peptide
amyloid precursor protein
Alzheimer's disease
neurodegenerative diseases
drug discovery
Antiamyloidogenic Activity of A beta 42-Binding Peptoid in Modulating Amyloid Oligomerization
期刊论文
SMALL, 2017
Zhao, Zijian
;
Zhu, Ling
;
Li, Haiyun
;
Cheng, Peng
;
Peng, Jiaxi
;
Yin, Yudan
;
Yang, Yang
;
Wang, Chen
;
Hu, Zhiyuan
;
Yang, Yanlian
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2017/12/04
aggregation,amyloid oligomerization,antiamyloidogenic,inhibitor,peptoids
GAMMA-SECRETASE INHIBITORS
SMALL-MOLECULE INHIBITORS
ALZHEIMERS-DISEASE
BETA-PEPTIDE
FIBRIL FORMATION
PROTEIN AGGREGATION
MOUSE MODEL
MECHANISM
NEUROTOXICITY
CONFORMATION
amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment
期刊论文
actapharmacologicasinica, 2017, 卷号: 38, 期号: 9, 页码: 1205
作者:
Chen Guofang
;
Xu Tinghai
;
Yan Yan
;
Zhou Yuren
;
Jiang Yi
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
BLOOD-BRAIN-BARRIER
INSULIN-DEGRADING ENZYME
SOLID-STATE NMR
NICOTINIC ACETYLCHOLINE-RECEPTORS
METABOTROPIC GLUTAMATE RECEPTORS
ATOMIC-FORCE MICROSCOPY
GAMMA-SECRETASE COMPLEX
SMOOTH-MUSCLE-CELLS
AMELIORATES MEMORY IMPAIRMENT
ENDOTHELIN-CONVERTING ENZYME
amyloid beta peptide
amyloid precursor protein
Alzheimer's disease
neurodegenerative diseases
drug discovery
Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 卷号: 112, 期号: 11, 页码: 3344-3349
作者:
Dang, SY
;
Wu, SJ
;
Wang, JW
;
Li, HB
;
Huang, M
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2015/07/22
intramembrane protease
Alzheimer's disease
PSH
gamma-secretase
beta-amyloid peptide
Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia
期刊论文
cancer research, 2014
Schubbert, Suzanne
;
Cardenas, Anjelica
;
Chen, Harrison
;
Garcia, Consuelo
;
Guo, Wei
;
Bradner, James
;
Wu, Hong
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2015/11/13
CANCER STEM-CELLS
GAMMA-SECRETASE INHIBITORS
BET BROMODOMAIN INHIBITION
ACUTE MYELOID-LEUKEMIA
AURORA KINASES
C-MYC
PTEN
NOTCH1
MUTATIONS
GROWTH
Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2012, 卷号: 55, 期号: 23, 页码: 10749-10765
作者:
Liu, Yanxia
;
Zhang, Wei
;
Li, Li
;
Salvador, Lilibeth A.
;
Chen, Tiantian
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2012, 卷号: 55, 期号: 23
Liu, YX
;
Zhang, W
;
Li, L
;
He, JH(何建华)
;
Xu, YC
;
Li, YX
;
Luesch, H
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2013/09/11
Small molecule inhibitors of amyloid beta peptide aggregation as a potential therapeutic strategy for Alzheimer's disease
期刊论文
ACTA PHARMACOLOGICA SINICA, 2011, 卷号: 32, 期号: 5, 页码: 545-551
作者:
Nie, Qin
;
Du, Xiao-guang
;
Geng, Mei-yu
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/01/08
Alzheimer's disease
amyloid beta peptide
protein-protein interaction
small molecule
Possible involvement of NO/NOS signaling in hippocampal amyloid-beta production induced by transient focal cerebral ischemia in aged rats
期刊论文
Neuroscience Letters, 2010, 卷号: Vol.470 No.2, 页码: 106
作者:
Li S
;
Wang W
;
Wang C
;
Tang YY
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/02/27
NITRIC-OXIDE
SYNTHASE
ALZHEIMERS-DISEASE
PRECURSOR
PROTEIN
ARTERY
OCCLUSION
GAMMA-SECRETASE
UP-REGULATION
BRAIN-INJURY
EXPRESSION
INHIBITORS
STRESS
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