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Treatment outcomes and prognosis of patients with primary and acquired BRAF-mutated non-small cell lung cancer: A multicenter retrospective study
期刊论文
GENES CHROMOSOMES & CANCER, 2022
作者:
Wang, Wenxian
;
Gu, Xiaodong
;
Si, Jinfei
;
Pu, Xingxiang
;
Wang, Liping
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/05/16
BRAF mutation
immune checkpoint inhibitors
non-small cell lung cancer
PD-L1
targeted therapy
Resistance mechanism of the oncogenic beta 3-alpha C deletion mutation in BRAF kinase to dabrafenib and vemurafenib revealed by molecular dynamics simulations and binding free energy calculations
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 93, 期号: 2, 页码: 177-187
作者:
Niu, Yuzhen
;
Zhang, Yan
;
Yao, Xiaojun
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
binding free energy calculation
BRAF inhibitors
drug resistance
molecular dynamics simulation
residue interaction network analysis
Dramatic efficacy of dabrafenib in Erdheim-Chester disease (ECD): a pediatric patient with multiple large intracranial ECD lesions hidden by refractory Langerhans cell histiocytosis
期刊论文
2019, 卷号: 23, 期号: 1, 页码: 48-53
作者:
Hao, Xiaolei
;
Feng, Ruie
;
Bi, Yalan
;
Liu, Yuhan
;
Li, Chunde
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/01/03
Erdheim-Chester disease
Langerhans cell histiocytosis
dabrafenib
brain tumor
oncology
treatment
aberrantmodulationofribosomalproteins6phosphorylationconfersacquiredresistancetomapkpathwayinhibitorsinbrafmutantmelanoma
期刊论文
中国药理学报英文版, 2019, 卷号: 040, 期号: 002, 页码: 268
作者:
Mingzhao Gao
;
Hongbin Wang
;
Xiangling Chen
;
Wenting Cao
;
Li Fu
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
BRAF-mutant
melanoma
MAPK
pathway
inhibitors
acquired
resistance
P70S6K
RSK
rpS6
G1/G0
phase
arrest
mTOR
inhibitor
Aberrant modulation of ribosomal protein S6 phosphorylation confers acquired resistance to MAPK pathway inhibitors in BRAF-mutant melanoma
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Gao, Ming-Zhao
;
Wang, Hong-Bin
;
Chen, Xiang-Ling
;
Cao, Wen-Ting
;
Fu, Li
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
BRAF and EGFR inhibitors synergize to increase cytotoxic effects and decrease stem cell capacities in BRAF(V600E)-mutant colorectal cancer cells
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 4
作者:
Wu, Zhenhua
;
Huang, Mingzhu
;
Gong, Yiwei
;
Lin, Chen
;
Guo, Weijian
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
BRAF inhibitor
dabrafenib
cetuximab
colorectal cancer
cancer stem cells
AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 489, 期号: 1, 页码: 14-20
作者:
Wang, Hongbin
;
Quan, Haitian
;
Lou, Liguang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Antagonism
AKT
BRAF
Dabrafenib
Sorafenib
Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf(V600E) inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 1059-1068
作者:
Wang, Gui-min
;
Wang, Xiang
;
Zhu, Jian-ming
;
Guo, Bin-bin
;
Yang, Zhuo
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
B-Raf(V600E) inhibitor
anticancer
vemurafenib
deazapurine
fragment reassembly
molecular docking
structure-activity relationship
Potential Drug-drug Interaction between Dabrafenib and Insulin Secretagogue Repaglinide
期刊论文
LATIN AMERICAN JOURNAL OF PHARMACY, 2017, 卷号: 36, 期号: 8
作者:
Wang, Yong-Gang
;
Wang, Shu-Dong
;
Miao, Xiao
;
Liu, Quan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
cancer
dabrafenib
drug-drug interaction
glucuronidation
repaglinide
type 2 diabetes mellitus (T2DM)
UDP-glucuronosyltransferase (UGT) 1A1
Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf~(V600E) inhibitors
期刊论文
Acta Pharmacologica Sinica, 2017, 卷号: 38, 期号: 7, 页码: 1057-1068
作者:
Wang Guimin
;
Wang Xiang
;
Zhu Jianming
;
Guo Binbin
;
Yang Zhuo
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
B-Raf~(V600E) inhibitor
anticancer
vemurafenib
deazapurine
fragment reassembly
molecular docking
structure-activity relationship
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