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科研机构
上海药物研究所 [1574]
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期刊论文 [1549]
会议论文 [19]
学位论文 [6]
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2021 [113]
2020 [113]
2019 [112]
2018 [140]
2017 [104]
2016 [93]
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Chemistry [18]
Biochemis... [13]
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共1574条,第1-10条
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Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2022, 卷号: 1867, 期号: 2, 页码: 13
作者:
Lu, Dasheng
;
Liu, Yameng
;
Luo, Yuhong
;
Zhao, Jie
;
Feng, Chao
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2022/01/18
Fatty acid oxidation
Acylcarnitines
FXR
FGF15/19
PGC1 alpha
Transcriptomics
Metabolomics
Application of metabolomics for revealing the interventional effects of functional foods on metabolic diseases
期刊论文
FOOD CHEMISTRY, 2022, 卷号: 367, 页码: 14
作者:
Fu, Jia
;
Zhang, Le-Le
;
Li, Wei
;
Zhang, Yan
;
Zhang, Yamei
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
Functional foods
Metabolomics
Metabolites
Metabolic diseases
Food processing
Novel pectin-like polysaccharide from Panax notoginseng attenuates renal tubular cells fibrogenesis induced by TGF-beta
期刊论文
CARBOHYDRATE POLYMERS, 2022, 卷号: 276, 页码: 12
作者:
Huang, Chunfan
;
Jing, Xiaoqi
;
Wu, Qianhu
;
Ding, Kan
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/12/16
Panax notoginseng
Polysaccharide
Renal fibrosis
Epithelial-mesenchymal transition
Pectin
A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters
期刊论文
CHEMICAL SCIENCE, 2021, 卷号: 13, 期号: 1, 页码: 247-256
作者:
Dong, Lei
;
Zhang, Min-Yu
;
Han, Hai-Hao
;
Zang, Yi
;
Chen, Guo-Rong
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/01/18
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression
期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 17
作者:
Li, Xinzhi
;
Yuan, Bingchuan
;
Lu, Min
;
Wang, Yuqin
;
Ding, Na
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2022/01/18
Eutectic molten salt assisted synthesis of highly defective and flexible ruthenium oxide for efficient overall water splitting
期刊论文
CHEMICAL ENGINEERING JOURNAL, 2021, 卷号: 425, 页码: 10
作者:
Peng, Chunlei
;
Zhao, Wanpeng
;
Li, Zhaoxia
;
Kuang, Zhaoyu
;
Cheng, Guofeng
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/01/04
Molten salt
Ruthenium oxide
Overall water splitting
Low-crystallinity
Nanosheets
New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Yong-Mei
;
Ye, Lu-Yu
;
Li, Tian-Yu
;
Guo, Fan
;
Guo, Fei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/01/04
YL-0919
medial prefrontal cortex
GABAergic neurons
5-HT1A receptor
GAD67-GFP transgenic mice
disinhibition
fluoxetine
electrophysiological recording
Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
期刊论文
ISCIENCE, 2021, 卷号: 24, 期号: 11, 页码: 22
作者:
Hu, Lin
;
Chen, Fuxian
;
Wu, Chao
;
Wang, Jun
;
Chen, Si-si
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/01/18
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Zou, Hui-xi
;
Zhang, Yu-feng
;
Zhong, Da-fang
;
Jiang, Yong
;
Liu, Fei
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/01/04
furmonertinib
autoinduction
food effect
alkaline phosphatase
body weight
pharmacokinetics
modeling and simulation
NSCLC
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