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科研机构
上海药物研究所 [30]
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期刊论文 [30]
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2020 [1]
2019 [1]
2018 [4]
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Quantitative analysis of fourteen bufadienolides in Venenum Bufonis crude drug and its Chinese patent medicines by ultra-high performance liquid chromatography coupled with tandem mass spectrometry
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2020, 卷号: 251, 页码: 8
作者:
Wei, Wen-long
;
An, Ya-ling
;
Zhang, Yan-zhi
;
Li, Zhen-wei
;
Zhou, Yang
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  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
Venenum Bufonis
Multi-component quantification
Quality evaluation
UHPLC-QqQ-MS/MS
RepSox, a small molecule inhibitor of the TGF beta receptor, induces brown adipogenesis and browning of white adipocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1523-1531
作者:
Tu, Wan-zhi
;
Fu, Yan-bin
;
Xie, Xin
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  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
RepSox
brown adipogenesis
TGF-beta receptor
TGF-beta inhibitor
adipocyte
differentiation
Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3808-3812
作者:
Zheng, Qiangang
;
Chen, Ziqi
;
Wan, Huixin
;
Tang, Shuai
;
Ye, Yan
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  |  
浏览/下载:234/0
  |  
提交时间:2019/01/08
IDH1 inhibitor
Imidazole cyclopropyl amine
Structure-based rational design
Deep eutectic solvents used as extraction solvent for the determination of flavonoids from Camellia oleifera flowers by high-performance liquid chromatography
期刊论文
PHYTOCHEMICAL ANALYSIS, 2018, 卷号: 29, 期号: 6, 页码: 639-648
作者:
Ma, Yaqian
;
Liu, Menghan
;
Tan, Ting
;
Yan, Aiping
;
Guo, Lan
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  |  
浏览/下载:71/0
  |  
提交时间:2019/01/08
Box-Behnken design
Camellia oleifera flowers
deep eutectic solvents
flavonoids
response surface methodology
Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 4, 页码: 587-596
作者:
Zheng, Yue-ming
;
Wang, Wan-fu
;
Li, Yan-fen
;
Yu, Yong
;
Gao, Zhao-bing
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  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
Nav1.7 channels
analgesics
CNV1014802
inactivated state
paroxysmal extreme pain disorder
Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 148, 页码: 140-153
作者:
Zha, Chuantao
;
Deng, Wenjia
;
Fu, Yan
;
Tang, Shuai
;
Lan, Xiaojing
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  |  
浏览/下载:68/0
  |  
提交时间:2019/01/08
Structure-based drug design
Selective CDK4/6 inhibitors
Structure-activity relationship study
In vivo antitumor activity
Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5262-5266
作者:
Zheng, Qiangang
;
Tang, Shuai
;
Fu, Xianlei
;
Chen, Ziqi
;
Ye, Yan
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  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
IDH1 inhibitor
Indane amide
Structure-based rational design
Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5332-5336
作者:
Fu, Yan
;
Tang, Shuai
;
Su, Yi
;
Lan, Xiaojing
;
Ye, Yan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Cyclin-dependent kinase
CDK inhibitor
Structure-activity relationship
In vitro and in vivo profiling
Nanobody-Based Apolipoprotein E Immunosensor for Point-of-Care Testing
期刊论文
ACS SENSORS, 2017, 卷号: 2, 期号: 9, 页码: 1267-1271
作者:
Ren, Xiang
;
Yan, Junrong
;
Wu, Dan
;
Wei, Qin
;
Wan, Yakun
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  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
nanobody
apolipoprotein E
point-of-care testing
colorimetric
immunosensor
With Guide of Spike-in Experiment for Optimizing Workflow of LC-MS data Processing in Metabolomics
期刊论文
NATURAL PRODUCT COMMUNICATIONS, 2017, 卷号: 12, 期号: 8, 页码: 1295-1300
作者:
Yan, Bing-peng
;
Cao, Chun-mei
;
Hou, Jin-jun
;
Bi, Qi-rui
;
Yang, Min
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  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
Metabolomics
Liquid chromatography-mass spectrometry (LC-MS)
Data processing
XCMS
Spike-in experiment
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