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科研机构
上海药物研究所 [11]
内容类型
期刊论文 [11]
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2021 [1]
2020 [2]
2019 [2]
2018 [4]
2010 [1]
2008 [1]
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Amygdalar k-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence
期刊论文
CELL REPORTS, 2021, 卷号: 37, 期号: 5, 页码: 21
作者:
Zan, Gui-Ying
;
Wang, Yu-Jun
;
Li, Xue-Ping
;
Fang, Jun-Fan
;
Yao, Song-Yu
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/12/16
The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-kappa B/NLRP3 signaling
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Yang, Fang-ming
;
Fan, Di
;
Yang, Xiao-qian
;
Zhu, Feng-hua
;
Shao, Mei-juan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/12/24
dry eye disease
artemisinin derivative
beta-aminoarteether maleate
inflammation
macrophages
TLR4
inflammasome
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 28, 页码: 9313-9325
作者:
Chang, Rulue
;
Zhang, Xin
;
Qiao, Anna
;
Dai, Antao
;
Belousoff, Matthew J.
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2020/12/24
glucagon receptor
glucagon-like peptide-1 receptor
dual agonist
cryo-electron microscopy
single particle analysis
structure-function
structural biology
peptide 15 (P15)
metabolic disorder
G protein?coupled receptor (GPCR)
glucagon
GLP-1 receptor
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:
Xiao, Li
;
Wang, Yujun
;
Zhang, Mumei
;
Wu, Weiwei
;
Kong, Linghui
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2020/07/01
USP9X stabilizes BRCA1 and confers resistance to DNA-damaging agents in human cancer cells
期刊论文
CANCER MEDICINE, 2019, 卷号: 8, 期号: 15, 页码: 6730-6740
作者:
Lu, Qin
;
Zhang, Fang-Lin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
BRCA1
breast cancer
deubiquitinase
PARP inhibitor
USP9X
7 beta-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 14, 页码: 4254-4263
作者:
Sun, Hui-jiao
;
Wang, Yu-hua
;
Yuan, Cong-min
;
Kong, Ling-hui
;
Xu, Xue-jun
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2019/01/08
7 beta-Methyl-nepenthone analogues
KOR ligands
Concept of hybridization
Opioid receptor binding and functional activities
(5R)-5-hydroxytriptolide ameliorates anti-glomerular basement membrane glomerulonephritis in NZW mice by regulating Fc gamma receptor signaling
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 1, 页码: 107-116
作者:
Qi, Qing
;
Li, Heng
;
Lin, Ze-min
;
Yang, Xiao-qian
;
Zhu, Feng-hua
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
triptolide
(5R)-5-hydroxytriptolide (LLDT-8)
prednisolone
glomerulonephritis
immune complexes
inflammation
Fc gamma receptor signaling
5r5hydroxytriptolideamelioratesantiglomerularbasementmembraneglomerulonephritisinnzwmicebyregulatingfcyreceptorsignaling
期刊论文
actapharmacologicasinica, 2018, 卷号: 39, 期号: 1, 页码: 107
作者:
Qi Qing
;
Li Heng
;
Lin Zemin
;
Yang Xiaoqian
;
Zhu Fenghua
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
triptolide
(5R)-5-hydroxytriptolide (LLDT-8)
prednisolone
glomerulonephritis
immune complexes
inflammation
Fcy receptor signaling
(5R)-5-hydroxytriptolide ameliorates anti-glomerular basement membrane glomerulonephritis in NZW mice by regulating Fcy receptor signaling
期刊论文
Acta Pharmacologica Sinica, 2018, 卷号: 39, 期号: 1, 页码: 107
作者:
Qi Qing
;
Li Heng
;
Lin Zemin
;
Yang Xiaoqian
;
Zhu Fenghua
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/12/24
triptolide
(5R)-5-hydroxytriptolide (LLDT-8)
prednisolone
glomerulonephritis
immune complexes
inflammation
Fcy receptor signaling
Expeditious preparation of triazole-linked glycolipids via microwave accelerated click chemistry and their electrochemical and biological assessments
期刊论文
TETRAHEDRON, 2010, 卷号: 66, 期号: 52, 页码: 9974-9980
作者:
Song, Shao-Xing
;
Zhang, Hai-Lin
;
Kim, Chol-Guk
;
Sheng, Li
;
He, Xiao-Peng
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Glycolipid derivatives
Microwave-assisted click chemistry
EIS measurement
Gold surface adsorption
Cytotoxicity
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