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科研机构
上海药物研究所 [19]
内容类型
期刊论文 [19]
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2021 [3]
2020 [2]
2019 [2]
2018 [1]
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A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters
期刊论文
CHEMICAL SCIENCE, 2021, 卷号: 13, 期号: 1, 页码: 247-256
作者:
Dong, Lei
;
Zhang, Min-Yu
;
Han, Hai-Hao
;
Zang, Yi
;
Chen, Guo-Rong
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/01/18
Discovery of a Potential Liver Fibrosis Inhibitor from a Mushroom Endophytic Fungus by Genome Mining of a Silent Biosynthetic Gene Cluster
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 卷号: 69, 期号: 38, 页码: 11303-11310
作者:
Cheng, Jin-Tao
;
Wang, Han-Min
;
Yu, Jia-Hui
;
Sun, Chen-Fan
;
Cao, Fei
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/12/01
fungus
Calcarisporium arbuscula
natural product
gene cluster activation
liver fibrosis
Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 7
作者:
Wang, Yi
;
Fang, Sui
;
Wu, Yan
;
Cheng, Xi
;
Zhang, Lei-ke
收藏
  |  
浏览/下载:105/0
  |  
提交时间:2021/08/17
SARS-CoV-2
envelope protein (2-E)
cation channel
high-throughput screening (HTS)
anti-virus
Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging
期刊论文
CHEMISTRY-A EUROPEAN JOURNAL, 2020, 页码: 9
作者:
Dong, Lei
;
Fu, Mengqi
;
Liu, Lifang
;
Han, Hai-Hao
;
Zang, Yi
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/12/21
cell imaging
glycoclusters
peroxynitrite detection
self-assembly
tetraphenylethylene
Active constituents and mechanisms of Respiratory Detox Shot, a traditional Chinese medicine prescription, for COVID-19 control and prevention: Network -molecular docking-LC-MSE analysis
期刊论文
JOURNAL OF INTEGRATIVE MEDICINE-JIM, 2020, 卷号: 18, 期号: 3, 页码: 229-241
作者:
Zhang, Zi-jia
;
Wu, Wen-yong
;
Hou, Jin-jun
;
Zhang, Lin-lin
;
Li, Fei-fei
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
Lung-toxin Dispelling Formula No. 1
COVID-19
3C-like protease
Network pharmacology
Molecular docking
Meridian tropism
Sarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.0(2,16)]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis
期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 84, 期号: 5, 页码: 2568-2576
作者:
Yang, Min
;
Li, Xiao-Lu
;
Wang, Jian-Rong
;
Lei, Xinxiang
;
Tang, Wei
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
Visualizing Autophagic Flux during Endothelial Injury with a Pathway-Inspired Tandem-Reaction Based Fluorogenic Probe
期刊论文
THERANOSTICS, 2019, 卷号: 9, 期号: 19, 页码: 5672-5680
作者:
Lei, Yu
;
Ren, Wenming
;
Wang, Cheng-Kun
;
Tao, Rong-Rong
;
Xiang, Huai-Jiang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Fluorescent imaging
fluorescent probe
autophagy
endothelial injury
H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018, 卷号: 341, 页码: 98-105
作者:
Yang, Yanting
;
Guan, Daokun
;
Lei, Lei
;
Lu, Jing
;
Liu, Jia Qi
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
alpha-Hederagenin
H6
Multidrug resistance
P-glycoprotein
Molecular docking
Design, synthesis and biological evaluation of novel alpha-hederagenin derivatives with anticancer activity
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 427-439
作者:
Liu, Xian-xuan
;
Yang, Yan-ting
;
Wang, Xiao
;
Wang, Kai-yi
;
Liu, Jia-qi
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
alpha-Hederagenin derivatives
Synthesis
Apoptosis
Cancer
Amino acids as co-amorphous excipients for tackling the poor aqueous solubility of valsartan
期刊论文
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2017, 卷号: 22, 期号: 1, 页码: 69-76
作者:
Huang, Ying
;
Zhang, Qi
;
Wang, Jian-Rong
;
Lin, Kai-Lei
;
Mei, Xuefeng
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Amino acid
co-amorphous
intrinsic dissolution rate
small molecular excipients
solubility
valsartan
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