QQ客服 官方微博 反馈留言

浏览/检索结果: 共13条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070 作者:  Xiao, Li;  Wang, Yujun;  Zhang, Mumei;  Wu, Weiwei;  Kong, Linghui 收藏  |  浏览/下载：92/0  |  提交时间：2020/07/01 Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 23 作者:  Zou, Yi;  Hu, Yue;  Ge, Shushan;  Zheng, Yingbo;  Li, Yuezhen 收藏  |  浏览/下载：34/0  |  提交时间：2020/07/01 IDO1  Heme  T cell  Cancer immunotherapy  Virtual screening  Drug design  Molecular dynamics simulation   Metabolic regulation of gene expression by histone lactylation 期刊论文 NATURE, 2019, 卷号: 574, 期号: 7779, 页码: 575-+ 作者:  Zhang, Di;  Tang, Zhanyun;  Huang, He;  Zhou, Guolin;  Cui, Chang 收藏  |  浏览/下载：41/0  |  提交时间：2020/07/01 Identifying the active components of Baihe-Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests 期刊论文 CHINESE MEDICINE, 2019, 卷号: 14, 期号: 1, 页码: 11 作者:  Zhong, Ming;  Tian, Xiaoting;  Chen, Shuoji;  Chen, Mingcang;  Guo, Ziqiong 收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01 Baihe-Zhimu decoction  Antidepressant  Timosaponin BII  Timosaponin BIII  Drug discovery   1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 448-456 作者:  Jiang, Junhang;  Zhang, Hao;  Wang, Chongqing;  Zhang, Qingsen;  Fang, Shaoyu 收藏  |  浏览/下载：16/0  |  提交时间：2020/07/01 Microtubule-targeting agents  Colchicine site inhibitors  Cis-trans photoisomerization  X-ray co-crystal structure  Water-soluble prodrug   Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes 期刊论文 NATURE CELL BIOLOGY, 2019, 卷号: 21, 期号: 8, 页码: 1015-+ 作者:  Sun, Lulu;  Wang, Yuqing;  Cen, Jin;  Ma, Xiaolong;  Cui, Lei 收藏  |  浏览/下载：26/0  |  提交时间：2020/07/01 SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC 期刊论文 AUTOPHAGY, 2019, 页码: 15 作者:  Zhang, Sulin;  Yang, Zhiwen;  Bao, Weilian;  Liu, Lixin;  You, Yan 收藏  |  浏览/下载：72/0  |  提交时间：2020/07/01 Colorectal cancer  macroautophagy  SNX10  SRC  tumor growth   Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 11, 页码: 5414-5433 作者:  Guo, Zuhao;  Zhang, Zhuqing;  Yang, Hong;  Cao, Danyan;  Xu, Xiaowei 收藏  |  浏览/下载：16/0  |  提交时间：2020/07/01 Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990 作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei 收藏  |  浏览/下载：39/0  |  提交时间：2020/07/01 cudc907displayspotentantitumoractivityagainsthumanpancreaticadenocarcinomainvitroandinvivothroughinhibitionofhdac6todownregulatecmycexpression 期刊论文 actapharmacologicasinica, 2019, 卷号: 40, 期号: 5, 页码: 677 作者:  Fu Xuhong;  Zhang Xiong;  Yang Hong;  Xu Xiaowei;  Hu Zonglong 收藏  |  浏览/下载：48/0  |  提交时间：2020/07/01 CANCER  GROWTH  TARGET  PI3K  ACTIVATION