Identifying the active components of Baihe-Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests

doi:10.1186/s13020-019-0254-9

	Identifying the active components of Baihe-Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests
	Zhong, Ming 1; Tian, Xiaoting 2; Chen, Shuoji 2; Chen, Mingcang 2; Guo, Ziqiong 2; Zhang, Minna 1; Zheng, Gongpu 1; Li, Zhixiong 2; Shi, Zhangpeng 2; Wang, Guanghui 1
刊名	CHINESE MEDICINE
	2019-09-24
卷号	14 期号:1 页码:11
关键词	Baihe-Zhimu decoction Antidepressant Timosaponin BII Timosaponin BIII Drug discovery
ISSN号	1749-8546
DOI	10.1186/s13020-019-0254-9
通讯作者	Liu, Fang(lf86614@126.com) ; Huang, Chenggang(cghsimm@126.com)
英文摘要	Background Modern pharmacological studies have demonstrated that Baihe-Zhimu decoction (BZD) has antidepressant effects. However, the complex composition and lack of clear evaluation standards for BZD make it less likely to be understood and accepted than evidence-based active natural compounds. Methods In this study, an effective method for the identification of antidepressant components was demonstrated and applied to BZD. The first step was to evaluate the efficacy of BZD by the forced swimming test (FST) and the tail suspension test (TST), followed by successive quantitative analyses of the absorbed constituents at different stages, such as before hepatic disposition, liver distribution, after hepatic disposition and brain distribution after the oral administration of BZD. Finally, the compounds detected in the brain were confirmed by activity testing. Results Our investigation observed that timosaponin BII and timosaponin BIII were accurately determined in the brain after oral administration of BZD, and they were further confirmed to reduce the immobility time in the FST and TST. As described above, timosaponin BII and timosaponin BIII were used to scientifically and reasonably explain the effective chemical basis of the effect of BZD on depression. Conclusions This research affords an effective method to discover lead molecules for antidepressants from traditional Chinese medicine.
资助项目	National Science and Technology Major Project of the Ministry of Science and Technology of China[2018ZX09731016-003] ; National Science and Technology Major Project of the Ministry of Science and Technology of China[2018ZX09201001-001-008] ; Focus on research and development plan in Shandong Province, China[2018GSF119006] ; National Natural Science Foundation of China[81803828] ; China Postdoctoral Science Foundation[2018M642123] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2019280]
WOS关键词	RAPID ANTIDEPRESSANT ; HERBAL MEDICINE ; IDENTIFICATION ; INVOLVEMENT ; EXTRACT ; PLASMA ; RATS
WOS研究方向	Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种	英语
出版者	BMC
WOS记录号	WOS:000487633300001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288522]
专题	中国科学院上海药物研究所
通讯作者	Liu, Fang; Huang, Chenggang
作者单位	1.Jining Med Univ, Coll Pharm, Rizhao 276826, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Materia Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhong, Ming,Tian, Xiaoting,Chen, Shuoji,et al. Identifying the active components of Baihe-Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests[J]. CHINESE MEDICINE,2019,14(1):11.
APA	Zhong, Ming.,Tian, Xiaoting.,Chen, Shuoji.,Chen, Mingcang.,Guo, Ziqiong.,...&Huang, Chenggang.(2019).Identifying the active components of Baihe-Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests.CHINESE MEDICINE,14(1),11.
MLA	Zhong, Ming,et al."Identifying the active components of Baihe-Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests".CHINESE MEDICINE 14.1(2019):11.