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Characteristics and mechanisms of polymer interfacial friction heating in ultrasonic plasticization for micro injection molding 期刊论文
Microsystem Technologies, 2017, 卷号: 23, 期号: 5, 页码: 1385-1392
作者:  Wu, Wangqing;  Peng, Huajian;  Jia, Yunlong;  Jiang, Bingyan*
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/03
Model test to investigate the failure mechanisms and lining stress characteristics of shallow buried tunnels under unsymmetrical loading 期刊论文
Tunnelling and Underground Space Technology, 2015, 卷号: 46, 页码: 64-75
作者:  Lei, Mingfeng;  Peng, Limin;  Shi, Chenghua*
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/03
Tartaric acid modified Pleurotus ostreatus for enhanced removal of Cr(VI) ions from aqueous solution: characteristics and mechanisms 期刊论文
RSC Advances, 2015, 卷号: 5, 期号: 31, 页码: 24009-24015
作者:  Xu, Weihua*;  Wang, Shufan;  Liu, Yunguo;  Zeng, Guangming;  Zheng, Bohong
收藏  |  浏览/下载:2/0  |  提交时间:2019/12/03
Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach 期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 4415-4426
作者:  Tang, Tian-Tian;  Hu, Xiong-Bin;  Liao, De-Hua;  Liu, Xin-Yi;  Xiang, Da-Xiong*
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/03
The purpose of the present work was to determine the mechanisms by which microemulsions (MEs) enhance the oral bioavailability of puerarin. The in situ perfusion method was used in rats to study the absorption mechanisms of an oil-in-water (O/W) microemulsion (O/W-ME) and a water-in-oil (W/O) microemulsion (W/O-ME). The possibility of lymphatic transport of the MEs was investigated using a chylomicron flow blocking approach. The results for the absorption mechanisms in the stomach and intestines indicated that the absorption characteristics of the O/W-ME and W/O-ME depend on the segment. The W/O-ME had higher internal membrane permeability than the O/W-ME. The results of the lymphatic transport analyses showed that both the O/W-ME and W/O-ME underwent lymphatic transport and that this pathway was a major contributor to the oral bioavailability of MEs. Furthermore  the type of ME can significantly affect the absorption of puerarin through the lymphatic system due to the oil content and the form of the microemulsion after oral administration. In conclusion  these data indicate that microemulsions are an effective and promising delivery system to enhance the oral bioavailability of poorly water-soluble drugs.  


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