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	Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach
	Tang, Tian-Tian; Hu, Xiong-Bin; Liao, De-Hua; Liu, Xin-Yi; Xiang, Da-Xiong*
刊名	International Journal of Nanomedicine
	2013
卷号	8期号:1页码:4415-4426
关键词	The purpose of the present work was to determine the mechanisms by which microemulsions (MEs) enhance the oral bioavailability of puerarin. The in situ perfusion method was used in rats to study the absorption mechanisms of an oil-in-water (O/W) microemulsion (O/W-ME) and a water-in-oil (W/O) microemulsion (W/O-ME). The possibility of lymphatic transport of the MEs was investigated using a chylomicron flow blocking approach. The results for the absorption mechanisms in the stomach and intestines indicated that the absorption characteristics of the O/W-ME and W/O-ME depend on the segment. The W/O-ME had higher internal membrane permeability than the O/W-ME. The results of the lymphatic transport analyses showed that both the O/W-ME and W/O-ME underwent lymphatic transport and that this pathway was a major contributor to the oral bioavailability of MEs. Furthermore the type of ME can significantly affect the absorption of puerarin through the lymphatic system due to the oil content and the form of the microemulsion after oral administration. In conclusion these data indicate that microemulsions are an effective and promising delivery system to enhance the oral bioavailability of poorly water-soluble drugs.
ISSN号	1178-2013
DOI	10.2147/IJN.S51469
URL标识	查看原文
WOS记录号	WOS:000327016100001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/3320623
专题	中南大学
作者单位	1.[Hu, Xiong-Bin 2.Liao, De-Hua 3.Liu, Xin-Yi 4.Xiang, Da-Xiong 5.Tang, Tian-Tian] Cent S Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.
推荐引用方式 GB/T 7714	Tang, Tian-Tian,Hu, Xiong-Bin,Liao, De-Hua,et al. Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach[J]. International Journal of Nanomedicine,2013,8(1):4415-4426.
APA	Tang, Tian-Tian,Hu, Xiong-Bin,Liao, De-Hua,Liu, Xin-Yi,&Xiang, Da-Xiong*.(2013).Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach.International Journal of Nanomedicine,8(1),4415-4426.
MLA	Tang, Tian-Tian,et al."Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach".International Journal of Nanomedicine 8.1(2013):4415-4426.

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