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科研机构
上海药物研究所 [193]
内容类型
期刊论文 [191]
会议论文 [2]
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2021 [13]
2020 [12]
2019 [11]
2018 [13]
2017 [8]
2016 [11]
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Chemistry [4]
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Forrestiacids A and B, Pentaterpene Inhibitors of ACL and Lipogenesis: Extending the Limits of Computational NMR Methods in the Structure Assignment of Complex Natural Products
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 7
作者:
Xiong, Juan
;
Zhou, Peng-Jun
;
Jiang, Hao-Wen
;
Huang, Ting
;
He, Yu-Hang
收藏
  |  
浏览/下载:89/0
  |  
提交时间:2021/11/04
forrestiacids
lipogenesis inhibitors
natural products
structure elucidation
terpenoids
Structural insights into the activation of human calcium-sensing receptor
期刊论文
ELIFE, 2021, 卷号: 10, 页码: 24
作者:
Chen, Xiaochen
;
Wang, Lu
;
Cui, Qianqian
;
Ding, Zhanyu
;
Han, Li
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2021/11/04
G-protein-coupled receptor
calcium-sensing receptor
cryo-electron microscopy
calcium ions
nanobody
CaSR
GPCR
cryo-EM
None
An enhanced strategy integrating offline two-dimensional separation with data independent acquisition mode and deconvolution: Characterization of metabolites of Uncaria rhynchophylla in rat plasma as a case
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1181, 页码: 8
作者:
Li, Haojv
;
Wei, Wenlong
;
Li, Zhenwei
;
Wang, Mengyuan
;
Wei, Xuemei
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2021/11/04
Off-line 2D separation system
Metabolites characterization in vivo
Data independent acquisition
Multi-dimensional deconvolution
Uncaria rhynchophylla
Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A(2A) Receptor Targeting the Sodium Ion Pocket
期刊论文
ACS CHEMICAL BIOLOGY, 2021, 卷号: 16, 期号: 6, 页码: 991-1002
作者:
Lu, Yan
;
Liu, Hongyue
;
Yang, Dehua
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  |  
浏览/下载:25/0
  |  
提交时间:2021/08/17
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target
期刊论文
CELL RESEARCH, 2021, 页码: 14
作者:
Xia, Bingqing
;
Shen, Xurui
;
He, Yang
;
Pan, Xiaoyan
;
Liu, Feng-Liang
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2021/08/17
Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap-Orbitrap mass spectrometry coupled with feature-based molecular networking
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 11
作者:
Chen, Ling
;
Yao, Changliang
;
Li, Jiayuan
;
Wang, Jing
;
Yao, Shuai
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/08/17
feature‐
based molecular networking
linear ion trap‐
Orbitrap
Mahuang decoction
traditional Chinese medicine
A strategy for practical authentication of medicinal plants in traditional Chinese medicine prescription, paeony root in ShaoYao-GanCao decoction as a case study
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 11
作者:
Cheng, Mengzhen
;
Yao, Changliang
;
Li, Yun
;
Li, Zhenwei
;
Li, Haojv
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/06/11
authentication
chemical markers
paeony root
selected ion monitoring
traditional Chinese medicine
A systematic strategy integrating solid-phase extraction, full scan range splitting, mass defect filter and precursor ion list for comprehensive metabolite profiling of Danqi Tongmai tablet in rats
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 9
作者:
Li, Zhen-wei
;
Wei, Wen-long
;
Li, Hao-jv
;
Wu, Shi-fei
;
Huang, Yong
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/05/24
Metabolite profiling
Solid-phase extraction
Mass defect filter
Precursor ion list
Danqi Tongmai tablet
Simultaneous determination of forsythin and its major metabolites in human plasma via liquid chromatography-tandem mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 7
作者:
Pan, Lu-lu
;
Chen, Tao
;
Hui, Min
;
Wang, Shuo
;
Fu, Li
收藏
  |  
浏览/下载:130/0
  |  
提交时间:2021/05/24
LC-MS/MS
Forsythin
Aglycone glucuronide
Aglycone sulfate
Pharmacokinetics
Characteristic Malonyl Ginsenosides from the Leaves of Panax notoginseng as Potential Quality Markers for Adulteration Detection
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 卷号: 69, 期号: 16, 页码: 4849-4857
作者:
Yao, Chang-liang
;
Wang, Jing
;
Li, Zhen-wei
;
Qu, Hua
;
Pan, Hui-qin
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2021/08/17
adulteration
Panax notoginseng leaves
malonyl ginsenosides
quality markers
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