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华中师范大学 [20]
山东大学 [16]
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厦门大学 [10]
复旦大学上海医学院 [9]
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期刊论文 [181]
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Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13
作者:
Chen, Yun
;
Bai, Gang
;
Li, Yan
;
Ning, Yi
;
Cao, Sufen
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/12/01
FLT3
FLT3-ITD
Acute myeloid leukemia
Structure-activity relationships
Pyrazolo[1, 5-a]pyrimidine
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18
作者:
Xu, Dandan
;
Sun, Deqiao
;
Wang, Wei
;
Peng, Xia
;
Zhan, Zhengsheng
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/08/17
Axl
Cancer
Inhibitor
Pyrrolo[2,3-d]pyrimidine
2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidines as new reversible inhibitors of EGFR C797S (Cys797 to Ser797) mutant
期刊论文
CHINESE CHEMICAL LETTERS, 2020, 卷号: 31, 期号: 5, 页码: 1281-1287
作者:
Hu, Xianglong
;
Xun, Qiuju
;
Zhang, Tao
;
Zhu, Su-Jie
;
Li, Qian
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
EGFR(C797S) mutant
SARs
2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidine
Clinical resistance
Fourth-generation inhibitors
Crystal structure of Arabidopsis thaliana cytidine deaminase
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 卷号: 529, 期号: 3, 页码: 659-665
作者:
Wang, Jia
;
Guo, Qi
;
Liu, Lin
;
Wang, Xiao
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/03/01
Pyrimidine metabolism
RNA editing
Crystallography
Catalytic mechanism
Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:
Yang, Xiuyan
;
Deng, Meng
;
Zhang, Xi
;
Wang, Yi
;
Song, Kun
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2020/07/01
PI3K alpha inhibitors
proliferation inhibition
thieno[3
2-d]pyrimidine derivatives
Synthesis and purification of biotinylated oligodeoxynucleotides containing single TpT dimeric pyrimidine (6-4) pyrimidone lesion
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2019, 卷号: 411, 期号: 18, 页码: 4123-4129
作者:
Wu, Danni
;
Zhang, Ning
;
Kong, Bingjie
;
Hang, Haiying
;
Wang, Hailin
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/10/21
UV irradiation
Pyrimidine (6-4) pyrimidone (6-4PP)
HPLC
UHPLC-Q-TOF/MS
Housecleaning of pyrimidine nucleotide pool coordinates metabolic adaptation of nongrowing Mycobacterium tuberculosis
期刊论文
EMERGING MICROBES & INFECTIONS, 2019, 卷号: 8, 期号: 1
作者:
Shi, Kun-Xiong
;
Wu, Yong-Kai
;
Tang, Bi-Kui
;
Zhao, Guo-Ping
;
Lyu, Liang-Dong
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
Mycobacterium tuberculosis
dormancy
nongrowing state
pyrimidine metabolism
mazG
Synthesis and biological evaluation of novel 1-substituted 3-(3-phenoxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 2
作者:
Zheng, Nan
;
Hao, Qun
;
Lin, Kuaile
;
Pan, Jing
;
Li, Yingxia
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
BTK inhibitors
1-Substituted pyrazolo[3,4-d]pyrimidine
Inhibitory activity
B-cell lymphoblastic leukemia
Cytotoxicity
Anticancer activity and mechanism of bis-pyrimidine based dimetallic Ru(II) (eta(6) -p-cymene) complex in human non-small cell lung cancer via p53-dependent pathway
期刊论文
JOURNAL OF INORGANIC BIOCHEMISTRY, 2019, 卷号: 194
作者:
Bhatti, Muhammad Zeeshan
;
Ali, Amjad
;
Duong, Hong-Quan
;
Chen, Jiwu
;
Rahman, Faiz-Ur
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
Anticancer complex
p53 activation
Cell migration
bis-Pyrimidine ligand
Ru-cymene
Enantioselective Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones through Organocatalytic Transfer Hydrogenation of 2-Hydroxypyrimidines
期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 4435-4442
作者:
Meng, Fan-Jie
;
Shi, Lei
;
Feng, Guang-Shou
;
Sun, Lei
;
Zhou, Yong-Gui
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/12/02
Enantioselectivity
Selective catalytic reduction, Chemoselective
Enantioselective synthesis
Hantzsch
Hydrogen sources
Organocatalytic
Stereogenic centers
Transfer hydrogenations, Hydrogenation, 3,4 dihydropyrimidin 2(1h)one
pyrimidine derivative
unclassified drug, Article
asymmetric synthesis
biomimetics
chirality
enantioselectivity
hydrogenation
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