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Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review) 期刊论文
INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 卷号: 52, 页码: 321-336
作者:  Rong, Biaoxue;  Yang, Shuanying
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/26
Folic acid-conjugated fluorescent polymer for up-regulation folate receptor expression study via targeted imaging of tumor cells 期刊论文
BIOSENSORS & BIOELECTRONICS, 2016, 卷号: 78, 页码: 147-153
作者:  Qiao, Juan;  Dong, Ping;  Mu, Xiaoyu;  Qi, Li;  Xiao, Ran
收藏  |  浏览/下载：19/0  |  提交时间：2016/05/03
Enhanced immunotherapy of SM5-1 in hepatocellular carcinoma by conjugating with gold nanoparticles and its in vivo bioluminescence tomographic evaluation 期刊论文
BIOMATERIALS, 2016
Ma, Xibo; Hui, Hui; Jin, Yushen; Dong, Di; Liang, Xiaolong; Yang, Xin; Tan, Ke; Dai, Zhifei; Cheng, Zhen; Tian, Jie
收藏  |  浏览/下载：7/0  |  提交时间：2017/12/03
Folic acid-conjugated fluorescent polymer for up-regulation folate receptor expression study via targeted imaging of tumor cells 期刊论文
2016, 卷号: 78, 页码: 147-153
作者:  Qiao, Juan;  Dong, Ping;  Mu, Xiaoyu;  Qi, Li;  Xiao, Ran
收藏  |  浏览/下载：3/0  |  提交时间：2020/01/04
Effects of abiotic stress and hormones on the expressions of five 13-CmLOXs and enzyme activity in oriental melon (Cucumis melo var. makuwa Makino) 期刊论文
JOURNAL OF INTEGRATIVE AGRICULTURE, 2016, 卷号: 15, 期号: 2, 页码: 326-338
作者:  Liu Jieying;  Zhang Chong;  Shao Qi;  Tang Yufan;  Cao Songxiao
收藏  |  浏览/下载：55/0  |  提交时间：2021/02/02
Effects of abiotic stress and hormones on the expressions of five 13-CmLOXs and enzyme activity in oriental melon (Cucumis melo var. makuwa Makino) 期刊论文
JOURNAL OF INTEGRATIVE AGRICULTURE, 2016, 卷号: 15, 期号: 2, 页码: 326-338
作者:  Liu Jieying;  Zhang Chong;  Shao Qi;  Tang Yufan;  Cao Songxiao
收藏  |  浏览/下载：51/0  |  提交时间：2021/02/02
Drosophila Pheromone-Sensing Neurons Expressing the ppk25 Ion Channel Subunit Stimulate Male Courtship and Female Receptivity 期刊论文
PLOS GENETICS, 2014, 卷号: 10, 期号: 3, 页码: 547-561
Vijayan, V; Thistle, R; Liu, T; Starostina, E; Pikielny, CW
收藏  |  浏览/下载：25/0  |  提交时间：2014/07/30
FAM3A Activates PI3K p110 alpha/Akt Signaling to Ameliorate Hepatic Gluconeogenesis and Lipogenesis 期刊论文
hepatology, 2014
Wang, Chunjiong; Chi, Yujing; Li, Jing; Miao, Yifei; Li, Sha; Su, Wen; Jia, Shi; Chen, Zhenzhen; Du, Shengnan; Zhang, Xiaoyan; Zhou, Yunfeng; Wu, Wenhan; Zhu, Mingyan; Wang, Zhiwei; Yang, Huaqian; Xu, Guoheng; Wang, Shiqiang; Yang, Jichun; Guan, Youfei
收藏  |  浏览/下载：9/0  |  提交时间：2015/11/11
Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118
作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03
DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.  
Phenanthrene exposure produces cardiac defects during embryo development of zebrafish (Danio rerio) through activation of MMP-9 期刊论文
http://dx.doi.org/10.1016/j.chemosphere.2013.06.056, 2013
Zhang, Youyu; Huang, Lixing; Wang, Chonggang; Gao, Dongxu; Zuo, Zhenghong; 王重刚; 左正宏
收藏  |  浏览/下载：6/0  |  提交时间：2015/07/22

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