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Key Considerations in Targeted Protein Degradation Drug Discovery and Development
期刊论文
FRONTIERS IN CHEMISTRY, 2022, 卷号: 10
作者:
Qin, Liena
;
Dai, Han
;
Wang, Junfeng
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  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
targeted protein degradation
PROTAC
molecular glue
chemically induced proximity
drug discovery and development
Protein degradation technology: a strategic paradigm shift in drug discovery
期刊论文
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 卷号: 14
作者:
Li, Haobin
;
Dong, Jinyun
;
Cai, Maohua
;
Xu, Zhiyuan
;
Cheng, Xiang-Dong
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  |  
浏览/下载:30/0
  |  
提交时间:2021/11/01
Protein degradation
Degradation pathway
Degradation technology
PROTAC
Monomeric degraders
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
期刊论文
FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 12
作者:
Qi, Si-Min
;
Dong, Jinyun
;
Xu, Zhi-Yuan
;
Cheng, Xiang-Dong
;
Zhang, Wei-Dong
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  |  
浏览/下载:47/0
  |  
提交时间:2021/06/15
PROTAC
E3 ubiquitin ligase
protein degradation
ubiquitin-proteasome system
cancer therapy
Balanced biosynthesis and trigger threshold resulting in a double adder mechanism of cell size control
期刊论文
COMMUNICATIONS IN THEORETICAL PHYSICS, 2021, 卷号: 73, 期号: 8, 页码: 85601
作者:
Li, Leilei
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  |  
浏览/下载:58/0
  |  
提交时间:2021/09/27
ESCHERICHIA-COLI
CHROMOSOME-REPLICATION
PROTEIN-DEGRADATION
GROWTH
HOMEOSTASIS
DIVISION
INITIATION
CYCLE
ADAPTATION
BACTERIA
On the modelling of tropical tree growth: the importance of intra-specific trait variation, non-linear functions and phenotypic integration
期刊论文
ANNALS OF BOTANY, 2021, 卷号: 127, 期号: 4, 页码: 533-542
作者:
Yang, Jie
;
Song, Xiaoyang
;
Cao, Min
;
Deng, Xiaobao
;
Zhang, Wenfu
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  |  
浏览/下载:51/0
  |  
提交时间:2021/06/16
BIG SEEDS1 (BS1)
F-box protein
MINI ORGAN1 (MIO1)/SMALL LEAF AND BUSHY1 (SLB1)
SCF E3 ligase
proteasome-mediated degradation
organ size
pulvinus
厌氧微生物在碳氮铁循环以及典型污染物迁移和转化中作用的机制研究
学位论文
北京: 中国科学院生态环境研究中心, 2020
作者:
周国伟
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浏览/下载:29/0
  |  
提交时间:2021/07/12
厌氧微生物 、土壤动物肠道 、 硝酸盐 /铁 还原 、 砷还原和甲基化 、水平基 因转移 、 蛋白质降解
Anaerobic Microorganism, Gut Microbiota, Nitrate/iron(Iii) Reduction, Arsenic Reduction And Methylation, Plasmid Conjugation, Protein Degradation
Design and synthesis of selective degraders of EGFR(L858R/T790M) mutant
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 192, 页码: 14
作者:
Zhang, Xin
;
Xu, Fang
;
Tong, Linjiang
;
Zhang, Tao
;
Xie, Hua
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  |  
浏览/下载:80/0
  |  
提交时间:2020/07/01
Epidermal growth factor receptor (EGFR)
Resistance
Proteolysis targeting chimera (PROTAC)
Protein degradation
Injectable hydrogels from enzyme-catalyzed crosslinking as BMSCs-laden scaffold for bone repair and regeneration
期刊论文
Materials Science and Engineering C, 2019, 卷号: 96, 页码: 841-849
作者:
Zhang, Yajie
;
Chen, Hong
;
Zhang, Tingting
;
Zan, Yue
;
Ni, Tianyu
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  |  
浏览/下载:49/0
  |  
提交时间:2019/11/19
Bone marrow-derived mesenchymal stem cells
Bone morphogenetic protein-2
Chondroitin sulfates
Degradation process
Horse-radish peroxidase
Injectable hydrogels
Mesenchymal stem cell
Osteogenic differentiation
Improvement in the Orthogonal Protein Degradation in Escherichia coli by Truncated mf-ssrA Tag
期刊论文
Transactions of Tianjin University, 2019, 卷号: Vol.25 No.4, 页码: 357-363
作者:
Lv, L.
;
Wu, Y.
;
Zhao, G.
;
Qi, H.
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  |  
浏览/下载:2/0
  |  
提交时间:2019/11/21
Escherichia coli
L region
mf-ssrA
Protein degradation
R region
Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing[S]
期刊论文
JOURNAL OF LIPID RESEARCH, 2019, 卷号: 60, 期号: 10
作者:
Chen, Liang
;
Ma, Mei-Yan
;
Sun, Ming
;
Jiang, Lu-Yi
;
Zhao, Xue-Tong
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  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
mevalonate
lanosterol
sterol intermediates
3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation
sterol regulatory element-binding protein-2 cleavage
clustered regularly interspaced short palindromic repeats (CRISPR)
CRISPR associated protein 9 (Cas9)
sterol regulatory element-binding protein-2
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