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浏览/检索结果: 共4条，第1-4条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 37, 页码: 16 作者:  Yang, Gui-Xiang;  Sun, Jia-Min;  Zheng, Lu-Lu;  Zhang, Li;  Li, Jie 收藏  |  浏览/下载：71/0  |  提交时间：2021/06/11 Vascular dementia  Diosgenin  Antioxidant  Anti-cholinesterase  Multi-target-directed ligands   Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates 期刊论文 European Journal of Medicinal Chemistry, 2017, 卷号: 138, 页码: 738-747 作者:  Zhao, Xiong-jie;  Gong, Da-min;  Jiang, Yu-ren*;  Guo, Dong;  Zhu, Yao 收藏  |  浏览/下载：56/0  |  提交时间：2019/12/03 Alzheimer's disease  Acetylcholinesterase  β-secretase  Metal chelators  Inhibitor  AChE  acetylcholinesterase  AChEIs  acetylcholinesterase inhibitors  Aβ  β-amyloid  AD  Alzheimer's disease  PAS  peripheral anionic sites  BACE-1  β-secretase  MTDLs  multi-target-directed ligands  PDB  Protein Data Bank  TLC  thin layer chromatography   (-)-Meptazinol-melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-beta aggregation with high antioxidant potency for Alzheimer's therapy 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 13 作者:  Cheng, Shaobing;  Zheng, Wei;  Gong, Ping;  Zhou, Qiang;  Xie, Qiong 收藏  |  浏览/下载：5/0  |  提交时间：2019/12/05 Alzheimer's disease  Multi-target-directed ligands  A beta aggregation  Antioxidant   (-)-Meptazinol-melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-beta aggregation with high antioxidant potency for Alzheimer's therapy 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 13 作者:  Cheng, Shaobing;  Zheng, Wei;  Gong, Ping;  Zhou, Qiang;  Xie, Qiong 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/19 Alzheimer's disease  Multi-target-directed ligands  A beta aggregation  Antioxidant