CORC

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CORC

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Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:  He, Qian;  Wei, Yuanyuan;  Liu, Xiao;  Ye, Rongrong;  Kong, Linghui
收藏  |  浏览/下载：88/0  |  提交时间：2021/11/04
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:  Xiao, Li;  Wang, Yujun;  Zhang, Mumei;  Wu, Weiwei;  Kong, Linghui
收藏  |  浏览/下载：92/0  |  提交时间：2020/07/01
Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12
作者:  Xu, Yulong;  Yang, Xicheng;  Chen, Yiyi;  Chen, Hao;  Sun, Huijiao
收藏  |  浏览/下载：5/0  |  提交时间：2019/12/05
Synthetic access to isoxazoline-functionalized isoquinolines via microwave-assisted iminoxyl radical-participated cascade cyclization of vinyl isocyanides 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2018, 卷号: 16, 期号: 27
作者:  Xu, Yulong;  Chen, Hao;  Li, Wei;  Xie, Qiong;  Yu, Linqian
收藏  |  浏览/下载：10/0  |  提交时间：2019/12/05
Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing alpha 7 nAChR activities 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160
作者:  Yang, Xicheng;  Shen, Jian;  Jiang, Lulu;  Li, Wei;  Yu, Mingcheng
收藏  |  浏览/下载：10/0  |  提交时间：2019/12/05
Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands 期刊论文
中国药理学报, 2017, 卷号: 38, 期号: 1
作者:  Shen Jian;  Yang Xicheng;  Yu Mingcheng;  Xiao Li;  Zhang Xunjie
收藏  |  浏览/下载：10/0  |  提交时间：2019/12/05
Microwave-Assisted Radical Insertion/Cyclization of Vinyl Isocyanides for the Synthesis of Multi-Substituted Isoquinolines 期刊论文
CHEMISTRYSELECT, 2017, 卷号: 2, 期号: 26
作者:  Xu, Yulong;  Chen, Hao;  Li, Wei;  Xie, Qiong;  Yu, Linqian
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/05
Microwave-assisted synthesis of hydroxyl-containing isoquinolines by metal-free radical cyclization of vinyl isocyanides with alcohols 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 卷号: 15, 期号: 47
作者:  Xue, Dengqi;  Chen, Hao;  Xu, Yulong;  Yu, Haihua;  Yu, Linqian
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/05
Concise Synthesis of Polycyclic Indoline Scaffolds through an In-III-Catalyzed Formal [4+2] Annulation of 2,3-Disubstituted Indoles with o-Aminobenzyl Alcohols 期刊论文
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017, 期号: 18
作者:  Luo, Mupeng;  Chen, Jianxin;  Yu, Linqian;  Wei, Wanguo
收藏  |  浏览/下载：7/0  |  提交时间：2019/12/05
Metal-free sulfonylation of quinones with sulfonyl hydrazides in water: Facile access to mono-sulfonylated hydroquinones 期刊论文
TETRAHEDRON, 2017, 卷号: 73, 页码: 2760-2765
作者:  Li, Bin[1];  Li, Yaqin[2];  Yu, Linqian[3];  Wu, Xiaoyu[4];  Wei, Wanguo[5]
收藏  |  浏览/下载：11/0  |  提交时间：2019/04/24

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