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浏览/检索结果: 共11条，第1-10条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of High-Affinity Inhibitors of the BPTF Bromodomain 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12075-12088 作者:  Lu, Tian;  Lu, Haibo;  Duan, Zhe;  Wang, Jun;  Han, Jie 收藏  |  浏览/下载：38/0  |  提交时间：2021/11/04 Discovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 3956-3975 作者:  Li, Zizhou;  Xiao, Senhao;  Yang, Yaxi;  Chen, Chao;  Lu, Tian 收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01 discoveryofnovelcbpbromodomaininhibitorsthroughtrfretbasedhighthroughputscreening 期刊论文 actapharmacologicasinica, 2020, 卷号: 41, 期号: 2, 页码: 285 作者:  Zhang Fengcai;  Sun Zhongya;  Liao Liping;  Zuo Yu;  Zhang Dan 收藏  |  浏览/下载：35/0  |  提交时间：2020/07/01 CBP bromodomain  small-molecule inhibitor  high-throughput screening  TR-FRET  molecular modeling  human leukemia MV4-11 cells   Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening 期刊论文 BIOORGANIC CHEMISTRY, 2019, 卷号: 86, 页码: 494-500 作者:  Zhang, Dan;  Han, Jie;  Lu, Wenchao;  Lian, Fulin;  Wang, Jun 收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01 Lysine acetylation  Bromodomain  Virtual screening  BPTF inhibitor   Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening 期刊论文 Bioorganic chemistry, 2019, 卷号: 86, 页码: 494-500 作者:  Zhang Dan[1];  Han Jie[2];  Lu Wenchao[3];  Lian Fulin[4];  Wang Jun[5] 收藏  |  浏览/下载：33/0  |  提交时间：2019/04/22 BPTF inhibitor  Bromodomain  Lysine acetylation  Virtual screening   Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 20, 页码: 5397-5407 作者:  Lu, Wenchao;  Xiong, Huan;  Chen, Yu;  Wang, Chen;  Zhang, Hao 收藏  |  浏览/下载：138/0  |  提交时间：2019/01/08 Drug discovery  Epigenetics  Histone acetyltransferase  P300/CBP   Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 80, 页码: 649-654 作者:  Zhang, Li;  Chen, Yantao;  Liu, Na;  Li, Linjuan;  Xiao, Senhao 收藏  |  浏览/下载：38/0  |  提交时间：2019/01/08 Pyrimidylaminoquinoline  Nonnucleoside DOT1L inhibitors  Amino side chains  Mixed-linage leukemia  Histone lysine methyltransferase   Design, synthesis and biological evaluation of benzo[cd]indo1-2(1H)-ones derivatives as BRD4 inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 264-273 作者:  Feng, Yuxin;  Xiao, Senhao;  Chen, Yantao;  Jiang, Hao;  Liu, Na 收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08 Benzo[cd]indol-2(1H)-one  Sulfonamide  BRD4 inhibitor  Bromodomain and extra-terminal domain  Acetyl-lysine binding pocket   Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1751-1758 作者:  Song, Yakai;  Li, Linjuan;  Chen, Yantao;  Liu, Jingqiu;  Xiao, Senhao 收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 DOT1L  MLL-rearranged leukemia  AlphaLISA  HTS  Novel inhibitors   Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors 期刊论文 Bioorganic & medicinal chemistry, 2018, 卷号: 26, 页码: 5397-5407 作者:  Lu Wenchao[1];  Xiong Huan[2];  Chen Yu[3];  Wang Chen[4];  Zhang Hao[5] 收藏  |  浏览/下载：14/0  |  提交时间：2019/04/22 Drug discovery  Epigenetics  Histone acetyltransferase  P300/CBP