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浏览/检索结果: 共18条，第1-10条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor-SN38 Conjugates for Targeted Drug Accumulation 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 10, 页码: 5421-5441 作者:  Zhu, Shulei;  Shen, Qianqian;  Gao, Yinglei;  Wang, Lei;  Fang, Yanfen 收藏  |  浏览/下载：8/0  |  提交时间：2020/12/24 Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure-activity relationship, crystal structural characterization and and in vivo study 期刊论文 ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 351-368 作者:  Wei, Peng;  Liu, Bo;  Wang, Ruifeng;  Gao, Yinglei;  Li, Lanlan 收藏  |  浏览/下载：103/0  |  提交时间：2020/07/01 Fibroblast growth factor  Tyrosine kinase receptor  Structure-based  Crystallography  Selectivity  Hybrid  5-Hydrosulfonyl-5H- pyrrolo[2.3-b]pyrazine  Inhibitor   Global liver disease burdens and research trends: Analysis from a Chinese perspective 期刊论文 JOURNAL OF HEPATOLOGY, 2019, 卷号: 71, 期号: 1 作者:  Xiao, Jia;  Wang, Fei;  Wong, Nai-Kei;  He, Jinhan;  Zhang, Rui 收藏  |  浏览/下载：23/0  |  提交时间：2019/12/04 Liver disease  Viral hepatitis  Non-alcoholic fatty liver disease  Alcoholic liver disease  Epidemiology  Research funding   discoveryofaseriesofdimethoxybenzenefgfrinhibitorswith5hpyrrolo23bpyrazinescaffoldstructureactivityrelationshipcrystalstructuralcharacterizationandinvivostudy 期刊论文 actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 2, 页码: 351 作者:  Wei Peng;  Liu Bo;  Wang Ruifeng;  Gao Yinglei;  Li Lanlan 收藏  |  浏览/下载：30/0  |  提交时间：2020/07/01 Fibroblast growth factor  Tyrosine kinase receptor  Structure-based  Crystallography  Selectivity  Hybrid  5-Hydrosulfonyl-5Hpyrrolo 2  3-bpyrazine  Inhibitor   Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer 期刊论文 Cancer Biology and Medicine, 2019, 卷号: 16, 期号: 1, 页码: 66 作者:  Wang Yuxiang;  Li Xian;  Liu Xueling;  Chen Yi;  Yang Chunhao 收藏  |  浏览/下载：13/0  |  提交时间：2020/12/24 PI3Kα  CDK4/6  KRAS  NSCLC  CYH33   simultaneousinhibitionofpi3kandcdk46synergisticallysuppresseskrasmutatednonsmallcelllungcancer 期刊论文 癌症生物学与医学英文版, 2019, 卷号: 016, 期号: 001, 页码: 66 作者:  Yuxiang Wang;  Xian Li;  Xueling Liu;  Yi Chen;  Chunhao Yang 收藏  |  浏览/下载：13/0  |  提交时间：2020/07/01 PI3Kα  CDK4/6  KRAS  NSCLC  CYH33   Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma 期刊论文 European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 671-689 作者:  Wang, Qi;  Dai, Yang;  Ji, Yinchun;  Shi, Huanyu;  Guo, Zuhao 收藏  |  浏览/下载：85/0  |  提交时间：2019/01/08 EZH2 inhibitors abrogate upregulation of H3K27me3 by CDK9 inhibitors and potentiate its antitumor activity in DLBCL 期刊论文 CANCER RESEARCH, 2018, 卷号: 78, 期号: 13, 页码: 2 作者:  Xie, Shao;  Wei, Fan;  Sun, Yiming;  Gao, Yinglei;  Ding, Jian 收藏  |  浏览/下载：2/0  |  提交时间：2020/07/01 Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models 期刊论文 MOLECULAR CANCER THERAPEUTICS, 2018, 卷号: 17, 期号: 4, 页码: 751-762 作者:  Ai, Jing;  Chen, Yi;  Peng, Xia;  Ji, Yinchun;  Xi, Yong 收藏  |  浏览/下载：50/0  |  提交时间：2019/01/08 Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 138, 页码: 514-531 作者:  Chen, Wenhua;  Guo, Ne;  Qi, Minghui;  Dai, Haiying;  Hong, Minghuang 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 Antitumor drug  BRCA1/2  PARP inhibitors  Molecular docking