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浏览/检索结果: 共6条，第1-6条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 23, 页码: 6206-6214 作者:  Zhang, Jiankang;  Gao, Lixin;  Xi, Jianjun;  Sheng, Li;  Zhao, Yanmei 收藏  |  浏览/下载：51/0  |  提交时间：2019/01/08 Proteasome inhibitors  Piperidine  Non-covalent  Anti-cancer  SARs   Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents 期刊论文 acs medicinal chemistry letters, 2013 Zhu, Yaoqiu; Zhou, Jiang; Jiao, Bo 收藏  |  浏览/下载：5/0  |  提交时间：2015/11/11 Clopidogrel resistance  clinical variability  prodrug attrition  piperidine deuteration  targeted metabolic shift  bioactivation potentiation  ADENOSINE DIPHOSPHATE  ACTIVE METABOLITE  BIOACTIVATION  RESISTANCE  IDENTIFICATION  AGGREGATION  INVOLVEMENT  TICLOPIDINE  PREVENTION  MECHANISM   Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11 beta-hydroxysteroid dehydrogenase type 1 期刊论文 MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012, 卷号: 358, 期号: 1, 页码: 46-52 作者:  Xia, Guangxin;  Liu, Lin;  Xue, Mengzhu;  Liu, Haiyan;  Yu, Jianxin 收藏  |  浏览/下载：13/0  |  提交时间：2019/01/08 11 beta-HSD1  Inhibitor  Sulfonamide  Diabetes  Docking   Identification of the Significant Involvement and Mechanistic Role of CYP3A4/5 in Clopidogrel Bioactivation 期刊论文 acs medicinal chemistry letters, 2012 Zhu, Yaoqiu; Zhou, Jiang 收藏  |  浏览/下载：4/0  |  提交时间：2015/11/11 Clopidogrel resistance  prodrug attrition  CYP3A4/5  active metabolite potentiation  piperidine metabolism  ANTIPLATELET TREATMENT  RESPONSE VARIABILITY  PLATELET REACTIVITY  CLINICAL-EFFICACY  CYP2C19 GENOTYPE  CYTOCHROMES P450  HIGHLY POTENT  IN-VITRO  METABOLISM  RISK   Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 卷号: 20, 期号: 17, 页码: 5334-5336 作者:  Li, Ben;  Jones, Eric Dale;  Zhou, Enkun;  Chen, Li;  Baylis, Dean Cameron 收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 CCR5 receptor antagonist  Anti-HIV   Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents 期刊论文 Bioorg. Med. Chem. Lett., 2010, 卷号: 20, 期号: 17, 页码: 5334-5336 李本; JONES ERIC DALE; ZHOU ENKUN; CHEN LI; BAYLIS DEAN CAMERON; 余尚海; 汪淼; HE XING; COATES JONATHAN ALAN VICTOR; RHODES DAVID IAN; 裴刚; DEADMAN JOHN JOSEPH; 谢欣; 马大为 收藏  |  浏览/下载：10/0  |  提交时间：2013/02/19