×
验证码:
换一张
忘记密码?
记住我
CORC
首页
科研机构
检索
知识图谱
申请加入
托管服务
登录
注册
在结果中检索
科研机构
上海药物研究所 [7]
吉林大学白求恩第一医... [4]
四川大学 [2]
复旦大学上海医学院 [2]
兰州大学 [1]
新疆理化技术研究所 [1]
更多...
内容类型
期刊论文 [20]
专利 [4]
发表日期
2021 [1]
2019 [5]
2018 [2]
2016 [2]
2014 [1]
2013 [4]
更多...
学科主题
urology & ... [1]
分析化学与药物化学 [1]
×
知识图谱
CORC
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
浏览/检索结果:
共24条,第1-10条
帮助
已选(
0
)
清除
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
作者升序
作者降序
题名升序
题名降序
发表日期升序
发表日期降序
提交时间升序
提交时间降序
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:
Qian, Hongjie
;
Chen, Qian
;
Lang, Liyu
;
Zou, Yang
;
Pu, Huahua
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/08/17
TPN171H
PDE5 inhibitor
safety
pharmacokinetics
food effect
healthy subjects
Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 172, 页码: 302-310
作者:
Pan, Lulu
;
Guo, Shuang
;
Chen, Xiaoyan
;
Jiang, Xiangrui
;
Shen, Jingshan
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2020/07/01
TPNI71
Metabolism
UPLC/Q-TOF MS
High-resolution mass spectrometry
Metabolite identification
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:
Wang, Zhen
;
Jiang, Xiangrui
;
Zhang, Xianglei
;
Tian, Guanghui
;
Yang, Rulei
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:
Wang, Z (Wang, Zhen)[ 1 ]
;
Jiang, XR (Jiang, Xiangrui)[ 1 ]
;
Zhang, XL (Zhang, Xianglei)[ 1,2 ]
;
Tian, GH (Tian, Guanghui)[ 3 ]
;
Yang, RL (Yang, Rulei)[ 3 ]
收藏
  |  
浏览/下载:137/0
  |  
提交时间:2019/06/28
Effect of phosphodiesterase type 5 inhibitors on prostate cancer risk and biochemical recurrence after prostate cancer treatment: A systematic review and meta-analysis
期刊论文
ANDROLOGIA, 2019, 卷号: 51, 期号: 2
作者:
Hong, Yang
;
Wu, Yougen
;
Qu, Xiaofeng
;
Wang, Yang
;
Xia, Ju
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/05
biochemical recurrence
meta-analysis
phosphodiesterase type 5 inhibitors
prostate cancer
The effect of CPAP and PDE5i on erectile function in men with obstructive sleep apnea and erectile dysfunction: A systematic review and meta-analysis
期刊论文
Sleep Medicine Reviews, 2019, 卷号: 48
作者:
Li Z.
;
Fang Z.
;
Xing N.
;
Zhu S.
;
Fan Y.
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
Continuous positive airway pressure
Erectile dysfunction
Obstructive sleep apnea
Phosphodiesterase type 5 inhibitors
Are phosphodiesterase type 5 inhibitors associated with increased risk of melanoma?
期刊论文
Medicine (Baltimore), 2018, 卷号: Vol.97 No.3, 页码: e9601
作者:
Shijian Feng
;
Liang Zhou
;
Qinyu Liu
;
Qing He
;
Banghua Liao
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/02/25
melanoma
phosphodiesterase type 5 inhibitor
risk factor
systematic review
Association between phosphodiesterase type 5 inhibitors use and risk of melanoma: a meta-analysis
期刊论文
2018, 卷号: 65, 期号: 2, 页码: 216
作者:
Deng, T.[1,2,3]
;
Duan, X.[1,2,3]
;
Liu, B.[4]
;
Lan, Y.[1,2,3]
;
Cai, C.[1,2,3]
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/17
Characterization of TPN729 metabolites in humans using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 卷号: 117, 页码: 217-226
作者:
Zhu, Yunting
;
Li, Liang
;
Deng, Pan
;
Chen, Xiaoyan
;
Zhong, Dafang
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
TPN729
UPLC/Q-TOF MS
Metabolite identification
Metabolic pathways
Human
Sildenafil
Systematic review and meta-analysis of phosphodiesterase type 5 inhibitors for the treatment of female sexual dysfunction
期刊论文
International Journal of Gynecology & Obstetrics, 2016, 卷号: Vol.133 No.2, 页码: 139-145
作者:
Liang Gao
;
Lu Yang
;
Shengqiang Qian
;
Tao Li
;
Ping Han
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/02/25
Female sexual dysfunction
Meta-analysis
Phosphodiesterase type 5 inhibitor (PDE5i)
Sildenafil
©版权所有 ©2017 CSpace - Powered by
CSpace