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SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target
期刊论文
CELL RESEARCH, 2021, 页码: 14
作者:
Xia, Bingqing
;
Shen, Xurui
;
He, Yang
;
Pan, Xiaoyan
;
Liu, Feng-Liang
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2021/08/17
Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 37, 页码: 16
作者:
Yang, Gui-Xiang
;
Sun, Jia-Min
;
Zheng, Lu-Lu
;
Zhang, Li
;
Li, Jie
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2021/06/11
Vascular dementia
Diosgenin
Antioxidant
Anti-cholinesterase
Multi-target-directed ligands
Multi-omics characterization of WNT pathway reactivation to ameliorate BET inhibitor resistance in liver cancer cells
期刊论文
GENOMICS, 2021, 卷号: 113, 期号: 3, 页码: 1057-1069
作者:
Liu, Yuwei
;
Xue, Mengzhu
;
Cao, Danyan
;
Qin, Lihuai
;
Wang, Ying
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  |  
浏览/下载:33/0
  |  
提交时间:2021/08/17
Multi-omics
BET inhibitor responses
WNT pathway
Liver cancer
Precise therapy
Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1)
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 195, 页码: 13
作者:
Zhang, Shiyan
;
Huang, Chaoying
;
Lyu, Xilin
;
Wang, Peipei
;
Zang, Yi
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  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
ASK1
ASK2
Selectivity
Apoptosis
Cell cycle arrest
Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10
作者:
Jiang, Zongru
;
Wang, Li
;
Liu, Xuesong
;
Chen, Cheng
;
Wang, Beilei
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  |  
浏览/下载:26/0
  |  
提交时间:2020/11/26
Cancer
VEGFR2 kinase
Kinase inhibitor
Angiogenesis
Inhibitor selectivity
Synthesis and Cdc25B/PTP1B Inhibitory Activity Evaluation of Novel Acylhydrazone Derivatives Containing Carbazole Moity
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 39, 期号: 2, 页码: 491-499
作者:
Li Yingjun
;
Wang Siyuan
;
Jin Kun
;
Gao Lixin
;
Sheng Li
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
acylhydrazone
carbazole
synthesis
Cdc25B and PTP1B inhibitor
molecular docking
Management of anlotinib-related adverse events in patients with advanced non-small cell lung cancer: Experiences in ALTER-0303.
期刊论文
Thoracic cancer, 2019, 卷号: 10, 页码: 551-556
作者:
Si Xiaoyan
;
Zhang Li
;
Wang Hanping
;
Zhang Xiaotong
;
Wang Mengzhao
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  |  
浏览/下载:35/0
  |  
提交时间:2019/11/19
non-small cell lung cancer
multi-target tyrosine kinase inhibitor
Adverse event
anlotinib
Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology
期刊论文
PLOS COMPUTATIONAL BIOLOGY, 2019, 卷号: 15, 期号: 6
作者:
Lim, Hansaim
;
He, Di
;
Qiu, Yue
;
Krawczuk, Patrycja
;
Sun, Xiaoru
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Management of anlotinib-related adverse events in patients with advanced non-small cell lung cancer: Experiences in ALTER-0303
期刊论文
THORACIC CANCER, 2019, 卷号: 10, 期号: 3, 页码: 551-556
作者:
Si, Xiaoyan
;
Zhang, Li
;
Wang, Hanping
;
Zhang, Xiaotong
;
Wang, Mengzhao
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/12/11
Adverse event
anlotinib
multi-target tyrosine kinase inhibitor
non-small cell lung cancer
Design, Synthesis and Biological Evaluation of Novel Osimertinib-Based HDAC and EGFR Dual Inhibitors
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 13
作者:
Dong, Hang
;
Yin, Hao
;
Zhao, Chunlong
;
Cao, Jiangying
;
Xu, Wenfang
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/12/11
HDAC
EGFR
multi-target inhibitor
antitumor
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