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Increased expression of G9A contributes to carcinogenesis and indicates poor prognosis in hepatocellular carcinoma 期刊论文
ONCOLOGY LETTERS, 2018, 卷号: 15, 期号: 6
作者:  Qin, Jian;  Li, Qingyun;  Zeng, Zhi;  Wu, Ping;  Jiang, Yanping
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/05
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation 期刊论文
Pharmacology and Therapeutics, 2015, 卷号: 151, 页码: 121-140
作者:  Liu, Ke;  Liu, Yanli;  Lau, Johnathan L;  Min, Jinrong*
收藏  |  浏览/下载:13/0  |  提交时间:2019/12/23
Histone demethylation  DNA methylation  Inhibitor  Chemical probe  Drug discovery  LSD  lysine-specific histone demethylase  HDAC  histone deacetylase  REST  REST corepressor  DNMT  DNA methyltransferase  MAO  monoamine oxidase  AML  acute myeloid leukemia  KDM  lysine-specific demethylase  MLL  mixed lineage leukemia  FAD  flavin adenine dinucleotide  PCPA  trans-2-phenylcyclopropylamine  2,4-PDCA  2, 4-pyridinedicarboxylic acid  PHD  plant homeobox domain  SCLC  small cell lung cancer  JHDMs  JmjC-domain-containing histone demethylases  NOG  N-oxalylglycine  IOX1  5-carboxy-8-hydroxyquinoline  MDS  myelodysplastic syndrome  2-OG, 2-oxoglutarate or  α-ketoglutarate  G9a  euchromatic histone-lysine N-methyltransferase 2  CoREST complex  restin corepressor complex  SAH  S-adenosyl-l-homocysteine  l  SWI complex  ATP dependent chromatin remodeling complexes  Pan-Histone Demethylase Inhibitor  the inhibitor can simultaneously inhibit both LSDs and JHDMs  LSC colony  leukemic stem cell colony  Pan JmjC domain-containing demethylase inhibitor  the inhibitor can simultaneously inhibit all the members of JHDMs  E2F1  E2F transcription factor 1  E2F2  E2F transcription factor 2  RCC  renal cell carcinoma  
Epigenetic targets and drug discovery: Part 1: Histone methylation 期刊论文
Pharmacology and Therapeutics, 2014, 卷号: 143, 期号: 3, 页码: 275-294
作者:  Liu, Yanli;  Liu, Ke;  Qin, Su;  Xu, Chao;  Min, Jinrong*
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/23
Epigenetics  Histone methylation  Inhibitor  Chemical probe  Cancer  PTM  posttranslational modification  HMTs  histone methyltrans-ferases  SET  Suv39, E(z) and Trithorax  SUV39  Su(var)3-9  SUV420  histone-lysine N-methyltransferase SUV420  G9a  euchromatic histone-lysine N-methyltransferase 2  GLP  G9a-like protein 1  Wiz  widely-interspaced zinc finger-containing protein  CDYL1  chromodomain Y-like protein  ACIN1  apoptotic chromatin condensation inducer in the nucleus  SAH  S-adenosyl-l-homocysteine  l  SAM  S-adenosylmethionine  Dot1  disruptor of telomeric silencing  Dot1L  DOT1-Like protein  EZH1  Enhancer of zeste homolog 1  EZH2  Enhancer of zeste homolog 2  Hox  homeotic box  PcG  Polycomb group  PRC1  Polycomb Repressive Complex 1  PRC2  Polycomb Repressive Complex 2  DZNep  3-Deazan- eplanocin A  SMYD2  SET and MYND domain-containing protein 2  PRMT  protein arginine methyltransferases  AMI-1  arginine methyltransferase inhibitor-1  MBT  Malignant Brain Tumor  PEV  position-effect variegation  HSPC  hematopoietic stem and progenitor cells  ChIP  chromatin immunoprecipitation  PK  pharmacokinetic  


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