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Low molecular weight fucoidan alleviates diabetic nephropathy by binding fibronectin and inhibiting ECM-receptor interaction in human renal mesangial cells
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 150, 页码: 304-314
作者:
Wang, Jing
;
Zhang, Quanbin
;
Li, Shuang
;
Chen, Zhihang
;
Tan, Jiaojiao
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2020/09/23
Fucoidan
ECM-receptor interaction
Fibronectin
MiR-874 alleviates renal injury and inflammatory response in diabetic nephropathy through targeting toll-like receptor-4
期刊论文
JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 卷号: 234, 期号: 1
作者:
Yao, Tao
;
Zha, Dongqing
;
Gao, Ping
;
Shui, Hua
;
Wu, Xiaoyan
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
diabetic nephropathy (DN)
miR-874
toll-like receptor 4 (TLR4)
magnesiumlithospermatebimprovesthegutmicrobiomeandbileacidmetabolicprofilesinamousemodelofdiabeticnephropathy
期刊论文
中国药理学报英文版, 2019, 卷号: 040, 期号: 004, 页码: 507
作者:
Jing Zhao
;
Qingli Zhang
;
Jianhua Shen
;
Kai Wang
;
Jia Liu
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
magnesium
lithospermate
B
diabetic
nephropathy
intestinal
microbiota
bile
acid
Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Zhao, Jing
;
Zhang, Qing-Li
;
Shen, Jian-Hua
;
Wang, Kai
;
Liu, Jia
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Quercetin ameliorates podocyte injury via inhibition of oxidative stress and the TGF-?1/Smad pathway in DN rats
期刊论文
RSC Advances, 2018, 卷号: 8, 页码: 35413-35421
作者:
Gao, Fanfan
;
He, Xin
;
Liang, Shanshan
;
Liu, Sixiu
;
Liu, Hua
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/11/19
Blood glucose level
Blood urea nitrogens
Diabetic nephropathy
Glomerular basement membrane
Intraperitoneal injections
Molecular mechanism
Protective effects
Signaling pathways
Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis
期刊论文
Redox Biology, 2018, 卷号: 16, 页码: 32-46
作者:
Han, Yachun
;
Xu, Xiaoxuan
;
Tang, Chengyuan
;
Gao, Peng
;
Chen, Xianghui
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/12/03
ALT
alanine aminotransferase
AST
aspartate aminotransferase
BUN
blood urea nitrogen
BW
body weight
BG
blood glucose
DCFDA
dichlorodihydrofluorescein diacetate
DN
diabetic nephropathy
ECL
enhanced chemiluminescence
EM
electron microscopy
EMT
epithelial–mesenchymal transition
HbA1C
hemoglobin A1c
HE
hematoxylin-eosin
IF
immunofluorescence
IHC
immunohistochemistry
KW
kidney weight
LDL
low-density lipoprotein
MDA
malondialdehyde
MFI
median fluorescence intensity
MMP
mitochondrial transmembrane potential
MMT
methyl methane-thiosulphonate
MPTP
mitochondrial permeability transition pore
MSU
monosodium urate
MtROS
mitochondria reactive oxygen species
PAS
periodic acid-Schiff
Scr
serum creatinine
TC
total cholesterol
TG
triglyceride
TBARS
thiobarbituric acid reactive substances
TPP
triphenylphosphonium
TRX
thioredoxin
TXNIP
thioredoxin-interacting protein
TUNEL
terminal deoxynucleotidyl transferase dUTP nick end-labeling
8-OHdG
8-oxo-deoxyguanosine
UA
uric acid
Diabetic nephropathy
Mitochondria
Reactive oxygen species (ROS)
TRX/TXNIP
NLRP3 inflammasome
MitoQ
Effect of HIF-1 alpha, VEGF and MVD expression on angiogenesis in diabetic nephropathy
期刊论文
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 卷号: 11, 期号: 2, 页码: 1247-1253
作者:
Zhang, Xiaomin
;
Ma, Lianhuan
;
Dong, Hua
;
Lv, Zhimei
;
Liu, Yunqi
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/11
Hypoxia-inducible factor1-alpha (HIF-1 alpha)
diabetic nephropathy
(DN)
vascular endothelial growth factor (VEGF)
microvessel density
(MVD)
Tangshen Formula Attenuates Diabetic Nephropathy by Promoting ABCA1-Mediated Renal Cholesterol Efflux in db/db Mice
期刊论文
2018, 卷号: 9
作者:
Liu, Peng
;
Peng, Liang
;
Zhang, Haojun
;
Tang, Patrick Ming-Kuen
;
Zhao, Tingting
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/01/03
Tangshen formula (TSF)
diabetic nephropathy (DN)
renal cholesterol efflux
ABCA1
Abca1-SiRNA
Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy
期刊论文
JOURNAL OF APPLIED PHYCOLOGY, 2017, 卷号: 29, 期号: 1, 页码: 531-542
作者:
Xu, Yingjie
;
Zhang, Quanbin
;
Luo, Dali
;
Wang, Jing
;
Duan, Delin
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2017/07/07
Fucoidan
Diabetic Nephropathy
Hspg
Glycosaminoglycan
Inflammatory Cytokines
Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc
期刊论文
Redox Biology, 2017, 卷号: 13, 页码: 482-497
作者:
Yang, Shikun
;
Zhao, Li
;
Han, Yachun
;
Liu, Yu
;
Chen, Chao
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/12/03
DN
diabetic nephropathy
ROS
reactive oxygen species
HG
high-glucose
SIRT1
sirtuin-1
Ac-H3
acetyl-histone H3
STZ
streptozotocin
AMPK
AMP-activated protein kinase
ECM
extracellular matrix
Nox2
NADPH oxidase 2
EMT
tubular epithelial-mesenchymal transition
DAPI
4′,6-diamidino-2-phenylindole 9
DHE
dihydroethidium
NDRD
non-diabetic renal disease
H&E
hematoxylin-eosin
PAS
periodic acid-Schiff
PASM
periodic acid-silver methenamine
IHC
immunohistochemistry
MDA
malondialdehyde
ChIP
chromatin immunoprecipitation
TC
total cholesterol
BUN
blood urea nitrogen
FN
fibronectin
HBA1C
glycosylated hemoglobin
Scr
serum creatinine
TG
triglyceride
Probucol
Renal injury
Diabetic nephropathy
p66Shc
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