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Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:
Hua, Chen
;
Shena, Lijuan
;
Zoua, Fengming
;
Wua, Yun
;
Wanga, Beilei
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/11/10
Acquired resistance mutations
CDK9 inhibitors
Transcription
Single nucleotide polymorphisms
BAY1251152
CDK9 inhibitors in cancer research
期刊论文
RSC MEDICINAL CHEMISTRY, 2022
作者:
Huang, Zhi
;
Wang, Tianqi
;
Wang, Cheng
;
Fan, Yan
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2022/12/23
Anti-DLBCL efficacy of DCZ0825 in vitro and in vivo: involvement of the PI3K-AKT-mTOR/JNK pathway
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021, 卷号: 53, 期号: 5, 页码: 575-583
作者:
Hu, Ke
;
Li, Bo
;
Ma, Ruye
;
Yi, Hongfei
;
Xu, Zhijian
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/06/11
caspase
cell proliferation
cell cycle arrest
diffuse large B-cell lymphoma
PI3K-AKT-mTOR/JNK pathway
Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 11
作者:
Qiu, Xiaqiu
;
Li, Yuanqing
;
Yu, Bin
;
Ren, Jie
;
Huang, Huidan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
CDK9
Antitumor
PROTAC
AML
Degrader
Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 178, 页码: 782-801
作者:
Wang, Jubo
;
Li, Tinghan
;
Zhao, Tengteng
;
Wu, Tizhi
;
Liu, Chuang
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Wogonin
CDK9
AML
Flavonoid
Antitumor
Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5332-5336
作者:
Fu, Yan
;
Tang, Shuai
;
Su, Yi
;
Lan, Xiaojing
;
Ye, Yan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Cyclin-dependent kinase
CDK inhibitor
Structure-activity relationship
In vitro and in vivo profiling
Protein Kinase Inhibitors as Potential Antimicrobial Drugs Against Tuberculosis, Malaria and HIV
期刊论文
CURRENT PHARMACEUTICAL DESIGN, 2017, 卷号: 23, 期号: 29, 页码: 4369-4389
作者:
Cheng, Yong
;
Schorey, Jeffrey S.
;
Zhang, Cheng-Cai
;
Tan, Xuejuan
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/07/03
Protein kinase inhibitors
antimicrobial drugs
infectious diseases
tuberculosis
malaria
AIDS
Development of Selective Cyclin-Dependent Kinase 4 Inhibitors for Antineoplastic Therapies
期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2017, 卷号: 17, 期号: 5
作者:
Guan, Haixing
;
Du, Yongli
;
Han, Weiwei
;
Shen, Jingkang
;
Li, Qunyi
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  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
Anti-cancer agents
cell cycle
clinical trials
cyclin-dependent kinases 4
selective inhibitors
structure activity relationship (SAR)
Development of Selective Cyclin-Dependent Kinase 4 Inhibitors for Antineoplastic Therapies
期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2017, 卷号: 17, 期号: 5, 页码: 646-657
作者:
Guan, Haixing
;
Du, Yongli
;
Han, Weiwei
;
Shen, Jingkang
;
Li, Qunyi
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Anti-cancer agents
cell cycle
clinical trials
cyclin-dependent kinases 4
selective inhibitors
structure activity relationship (SAR)
An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 21, 页码: 9575-9598
作者:
Wang, Ying-Qing
;
Wang, Ping-Yuan
;
Wang, Yu-Ting
;
Yang, Guang-Fu
;
Zhang, Ao
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
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